Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,

Bone ◽  
2003 ◽  
Vol 33 (6) ◽  
pp. 919-926 ◽  
Author(s):  
K Stenderup
Keyword(s):  
Bone Marrow ◽  
Life Span ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Maximal Life Span ◽  
Accelerated Senescence

scholarly journals Combination of hTERT and bmi-1, E6, or E7 Induces Prolongation of the Life Span of Bone Marrow Stromal Cells from an Elderly Donor without Affecting Their Neurogenic Potential

2005 ◽  
Vol 25 (12) ◽  
pp. 5183-5195 ◽  
Author(s):  
Taisuke Mori ◽  
Tohru Kiyono ◽  
Hideaki Imabayashi ◽  
Yukiji Takeda ◽  
Kohei Tsuchiya ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Life Span ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Murine Bone Marrow ◽  
Differentiated Cells ◽  
E6 And E7 ◽  
Old Donor

ABSTRACT Murine bone marrow stromal cells differentiate not only into mesodermal derivatives, such as osteocytes, chondrocytes, adipocytes, skeletal myocytes, and cardiomyocytes, but also into neuroectodermal cells in vitro. Human bone marrow stromal cells are easy to isolate but difficult to study because of their limited life span. To overcome this problem, we attempted to prolong the life span of bone marrow stromal cells and investigated whether bone marrow stromal cells modified with bmi-1, hTERT, E6, and E7 retained their differentiated capability, or multipotency. In this study, we demonstrated that the life span of bone marrow stromal cells derived from a 91-year-old donor could be extended and that the stromal cells with an extended life span differentiated into neuronal cells in vitro. We examined the neuronally differentiated cells morphologically, physiologically, and biologically and compared the gene profiles of undifferentiated and differentiated cells. The neuronally differentiated cells exhibited characteristics similar to those of midbrain neuronal progenitors. Thus, the results of this study support the possible use of autologous-cell graft systems to treat central nervous system diseases in geriatric patients.

Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells

2002 ◽  
Vol 20 (6) ◽  
pp. 592-596 ◽  
Author(s):  
Janne L. Simonsen ◽  
Cecilia Rosada ◽  
Nedime Serakinci ◽  
Jeannette Justesen ◽  
Karin Stenderup ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Life Span ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Osteogenic Potential

Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

2013 ◽  
Author(s):  
Sylvia Thiele ◽  
Alexander Rauch ◽  
Jan P Tuckermann ◽  
Lorenz C Hofbauer ◽  
Martina Rauner
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells
Sign in / Sign up

Export Citation Format

Share Document