Antimicrobial evaluation and action mechanism of pyridinium-decorated 1,4-pentadien-3-one derivatives

2018 ◽  
Vol 28 (10) ◽  
pp. 1742-1746 ◽  
Author(s):  
Jian Zhou ◽  
Qing-Qing Tao ◽  
Pei-Yi Wang ◽  
Wu-Bin Shao ◽  
Zhi-Bing Wu ◽  
...  
Keyword(s):  
Action Mechanism ◽  
Antimicrobial Evaluation

Antimicrobial evaluation and action mechanism of chalcone derivatives containing quinoxaline moiety

2019 ◽  
Vol 150 (7) ◽  
pp. 1325-1334 ◽  
Author(s):  
Rongjiao Xia ◽  
Tao Guo ◽  
Jun He ◽  
Mei Chen ◽  
Shijun Su ◽  
...  
Keyword(s):  
Action Mechanism ◽  
Chalcone Derivatives ◽  
Antimicrobial Evaluation

Coumarin-derived azolyl ethanols: synthesis, antimicrobial evaluation and preliminary action mechanism

2016 ◽  
Vol 59 (7) ◽  
pp. 878-894 ◽  
Author(s):  
Xin-Mei Peng ◽  
Kannekanti Vijaya Kumar ◽  
Guri L.V. Damu ◽  
Cheng-He Zhou
Keyword(s):  
Action Mechanism ◽  
Antimicrobial Evaluation

Tribological Performance and Action Mechanism of Cadmium Dialkyldithiophosphate

2005 ◽  
Vol 48 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Hu Jianqiang ◽  
Wei Xianyong ◽  
Yao Junbing ◽  
Xie Feng ◽  
Zhu Huanqin ◽  
...  
Keyword(s):  
Tribological Performance ◽  
Action Mechanism

The Action Mechanism of the Purified Platelet Aggregation Principle of Trimeresurus mucrosquamatus Venom

1979 ◽  
Vol 41 (03) ◽  
pp. 475-490 ◽  
Author(s):  
Chaoho Ouyang ◽  
Che-Ming Teng
Keyword(s):  
Platelet Aggregation ◽  
Adenine Nucleotides ◽  
Muscle Relaxants ◽  
Prostaglandin Synthesis ◽  
Action Mechanism ◽  
Crude Venom ◽  
Platelet Factor ◽  
Induce Platelet Aggregation ◽  
Minimal Concentration ◽  
Aggregation Principle

SummaryThe minimal concentration of the platelet aggregation principle (Platelet Aggregoserpen- tin, PAS) necessary to induce platelet aggregation was 10 ng/ml, about one-hundredth of that of the crude venom. PAS induced the release of platelet factors 3 and 4 from platelets, but the released platelet factor 3 was easily inactivated by the anti-phospholipid effect of PAS. Pretreatment of platelets with neuraminidase potentiated PAS-induced platelet aggregation. PAS-induced platelet aggregation was independent on released ADP; it could occur in the ADP-removing systems, such as apyrase or a combination of phosphoenolpyruvate and pyruvate kinase. However, PAS-induced platelet aggregation could be inhibited by adenine nucleotides and adenosine.PAS-induced platelet aggregation was inhibited by some anti-inflammatory agents, antimalarial drugs, local anesthetics, antihistamine and smooth muscle relaxants. After deaggregation of PAS-treated platelets, thrombin and sodium arachidonate could further induce platelet aggregation, but ADP and second dose of PAS could not. It is concluded that PAS-induced platelet aggregation is due to prostaglandin synthesis. Recent literatures on the mechanism of platelet aggregation were surveyed and the actions of PAS were discussed.

Synthesis and Antimicrobial Evaluation of Some New Pyrazoline Derivatives

2011 ◽  
Vol 3 (8) ◽  
pp. 72-73 ◽  
Author(s):  
Kendre M. M Kendre M. M ◽  
◽  
M. A. Baseer M. A. Baseer
Keyword(s):  
Antimicrobial Evaluation

Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

2018 ◽  
Vol 18 (15) ◽  
pp. 1275-1286 ◽  
Author(s):  
Luiz Felipe Domingues Passero ◽  
Lucas Antal Cruz ◽  
Gabriela Santos-Gomes ◽  
Eliana Rodrigues ◽  
Márcia Dalastra Laurenti ◽  
...  
Keyword(s):  
Side Effects ◽  
Visceral Leishmaniasis ◽  
Traditional Knowledge ◽  
Conventional Therapy ◽  
Pathogenic Species ◽  
Action Mechanism ◽  
In Vivo Assays ◽  
Clinical Forms

Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in most cases, are considered outdated. In addition, patients under classical treatment show serious side effects during drug administration, moreover parasites are able to become resistant to medicines. Thus, it is believed and well accepted that is urgent and necessary to develop new therapeutic options to overpass these concerns about conventional therapy of leishmaniasis. The present review will focus on the efficacy, side effects and action mechanism of classic drugs used in the treatment of leishmaniasis, as well as the importance of traditional knowledge for directing a rational search toward the discovery and characterization of new and effective molecules (in vivo assays) from plants to be used against leishmaniasis.

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