The first total synthesis and biological evaluation of marine natural products ma’edamines A and B

2013 ◽  
Vol 23 (4) ◽  
pp. 1013-1016 ◽  
Author(s):  
Sanjay Saha ◽  
Ch. Venkata Ramana Reddy ◽  
T. Chiranjeevi ◽  
Uma Addepally ◽  
T.S. Chinta Rao ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Total synthesis and biological evaluation of ustiloxin natural products and two analogs

2006 ◽  
Vol 16 (18) ◽  
pp. 4804-4807 ◽  
Author(s):  
Pixu Li ◽  
Cory D. Evans ◽  
Erin M. Forbeck ◽  
Haengsoon Park ◽  
Ruoli Bai ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Total Synthesis and Biological Evaluation of Phaeosphaerides

Catalysts ◽  
2018 ◽  
Vol 8 (5) ◽  
pp. 206 ◽  
Author(s):  
Kenichi Kobayashi ◽  
Kosaku Tanaka ◽  
Hiroshi Kogen
Keyword(s):  
Crystal Structure ◽  
Natural Products ◽  
Total Synthesis ◽  
Structure Analysis ◽  
Endophytic Fungus ◽  
Biological Evaluation ◽  
Crystal Structure Analysis ◽  
X Ray ◽  
Structure Activity ◽  
Synthesis And Biological Evaluation

This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. Structure–activity relationship studies of phaeosphaeride derivatives are also discussed.

Synthesis and Biological Evaluation of Imidazoquinoxalinones, Imidazole Analogues of Pyrroloiminoquinone Marine Natural Products

2007 ◽  
Vol 50 (19) ◽  
pp. 4561-4571 ◽  
Author(s):  
Hung Hoang ◽  
Daniel V. LaBarbera ◽  
Kaleem A. Mohammed ◽  
Chris M. Ireland ◽  
Edward B. Skibo
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A

2010 ◽  
Vol 132 (21) ◽  
pp. 7540-7548 ◽  
Author(s):  
K. C. Nicolaou ◽  
Qiang Kang ◽  
T. Robert Wu ◽  
Chek Shik Lim ◽  
David Y.-K. Chen
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

Total Synthesis and Biological Evaluation of Ustiloxin Natural Products and Two Analogues.

ChemInform ◽  
2007 ◽  
Vol 38 (1) ◽  
Author(s):  
Pixu Li ◽  
Cory D. Evans ◽  
Erin M. Forbeck ◽  
Haengsoon Park ◽  
Ruoli Bai ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and biological evaluation of 1,2-disubsubstituted 4-quinolone analogues ofPseudonocardiasp. natural products

2018 ◽  
Vol 14 ◽  
pp. 2680-2688
Author(s):  
Stephen M Geddis ◽  
Teodora Coroama ◽  
Suzanne Forrest ◽  
James T Hodgkinson ◽  
Martin Welch ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Bacterial Species ◽  
Biological Evaluation ◽  
Human Pathogen ◽  
Growth Defects ◽  
Structure Activity ◽  
Related Series ◽  
Relationship Of ◽  
Synthesis And Biological Evaluation

A series of analogues ofPseudonocardiasp. natural products were synthesized, which have been reported to possess potent antibacterial activity againstHelicobacter pyloriand induce growth defects inEscherichia coliandStaphylococcus aureus. Taking inspiration from a methodology used in our total synthesis of natural products, we applied this methodology to access analogues possessing bulky N-substituents, traditionally considered to be challenging scaffolds. Screening of the library provided valuable insights into the structure–activity relationship of the bacterial growth defects, and suggested that selectivity between bacterial species should be attainable. Furthermore, a structurally related series of analogues was observed to inhibit production of the virulence factor pyocyanin in the human pathogenPseudomonas aeruginosa, which may be a result of their similarity to thePseudomonasquinolone signal (PQS) quorum sensing autoinducer. This provided new insights regarding the effect of N-substitution in PQS analogues, which has been hitherto underexplored.

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