Design and synthesis of novel enhanced water soluble hydroxyethyl analogs of combretastatin A-4

2011 ◽  
Vol 21 (7) ◽  
pp. 2087-2091 ◽  
Author(s):  
Megan Lee ◽  
Olivia Brockway ◽  
Armaan Dandavati ◽  
Samuel Tzou ◽  
Robert Sjoholm ◽  
...  
Keyword(s):  
Water Soluble ◽  
Design And Synthesis

The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent

2002 ◽  
Vol 45 (17) ◽  
pp. 3692-3702 ◽  
Author(s):  
V. Bavetsias ◽  
L. A. Skelton ◽  
F. Yafai ◽  
F. Mitchell ◽  
S. C. Wilson ◽  
...  
Keyword(s):  
Antitumor Agent ◽  
Water Soluble ◽  
Design And Synthesis

Design and Synthesis of Highly Luminescent Near-Infrared-Emitting Water-Soluble CdTe/CdSe/ZnS Core/Shell/Shell Quantum Dots

2009 ◽  
Vol 48 (20) ◽  
pp. 9723-9731 ◽  
Author(s):  
Wenjin Zhang ◽  
Guanjiao Chen ◽  
Jian Wang ◽  
Bang-Ce Ye ◽  
Xinhua Zhong
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Water Soluble ◽  
Core Shell ◽  
Design And Synthesis

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

2019 ◽  
Vol 30 (1) ◽  
pp. 247-249 ◽  
Author(s):  
Xingjie Zhang ◽  
Zhi Meng ◽  
Zhiqiang Ma ◽  
Junhong Liu ◽  
Guiyan Han ◽  
...  
Keyword(s):  
Amino Acid ◽  
Water Soluble ◽  
Amino Acid Derivatives ◽  
Design And Synthesis ◽  
Derivatives Of ◽  
Chlorin P6

ChemInform Abstract: Design and Synthesis of a Novel Water Soluble Benzotetrazepinone.

ChemInform ◽  
2001 ◽  
Vol 32 (4) ◽  
pp. no-no
Author(s):  
Beatrice Dumont-Hornebeck ◽  
Yi Ning Strube ◽  
Daniela Vasilescu ◽  
Bertrand Jacques Jean-Claude
Keyword(s):  
Water Soluble ◽  
Design And Synthesis

A Novel Approach of Water-Soluble Paclitaxel Prodrug with No Auxiliary and No Byproduct:  Design and Synthesis of Isotaxel

2003 ◽  
Vol 46 (18) ◽  
pp. 3782-3784 ◽  
Author(s):  
Yoshio Hayashi ◽  
Mariusz Skwarczynski ◽  
Yoshio Hamada ◽  
Youhei Sohma ◽  
Tooru Kimura ◽  
...  
Keyword(s):  
Water Soluble ◽  
Design And Synthesis ◽  
Novel Approach

The Rational Design and Synthesis of Water-Soluble Thiourea Ligands for Recoverable Pd-Catalyzed Aerobic Aqueous Suzuki–Miyaura Reactions at Room Temperature

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1499-1510 ◽  
Author(s):  
Wei Chen ◽  
Xiao-Yan Lu ◽  
Bei-Hua Xu ◽  
Wei-guo Yu ◽  
Zi-niu Zhou ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Rational Design ◽  
Pd Nanoparticles ◽  
Water Soluble ◽  
Tem Analysis ◽  
Arylboronic Acids ◽  
Design And Synthesis ◽  
Black Precipitate ◽  
Aryl Bromides ◽  
Carboxylic Groups

Eight precatalysts containing carboxylic-functionalized thiourea ligands are prepared and their activities and recyclability are evaluated in aerobic aqueous Suzuki–Miyaura reactions. A bulky monothiourea–Pd complex, functionalized with four carboxylic groups, shows the best activity and recyclability in the coupling of aryl bromides with arylboronic acids. The catalyst can be reused at least five times without any significant reduction in its catalytic activity. TEM analysis and the confirmed catalytic activity of the observed black precipitate reveal that Pd nanoparticles are formed during the reactions and are stabilized by the carboxylic-functionalized thiourea ligands.

scholarly journals Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells

2021 ◽  
Vol 22 (18) ◽  
pp. 9976
Author(s):  
Jose Maria Zapico ◽  
Lourdes Acosta ◽  
Miryam Pastor ◽  
Loganathan Rangasamy ◽  
Laura Marquez-Cantudo ◽  
...  
Keyword(s):  
Water Soluble ◽  
Osteosarcoma Cells ◽  
Design And Synthesis ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells ◽  
Joint Disorder ◽  
Molecular Modeling Studies ◽  
Inflammatory Drugs ◽  
New Treatments ◽  
Benzotriazole Derivatives

Osteoarthritis is a degenerative disease, often resulting in chronic joint pain and commonly affecting elderly people. Current treatments with anti-inflammatory drugs are palliative, making the discovery of new treatments necessary. The inhibition of matrix metalloproteinase MMP-13 is a validated strategy to prevent the progression of this common joint disorder. We recently described polybrominated benzotriazole derivatives with nanomolar inhibitory activity and a promising selectivity profile against this collagenase. In this work, we have extended the study in order to explore the influence of bromine atoms and the nature of the S1′ heterocyclic interacting moiety on the solubility/selectivity balance of this type of compound. Drug target interactions have been assessed through a combination of molecular modeling studies and NMR experiments. Compound 9a has been identified as a water-soluble and highly potent inhibitor with activity in MG-63 human osteosarcoma cells.

Design and synthesis of water-soluble polyaminated chlorins and bacteriochlorins – With near-infrared absorption

2013 ◽  
Vol 98 (3) ◽  
pp. 609-614 ◽  
Author(s):  
Nicolas Drogat ◽  
Christelle Gady ◽  
Robert Granet ◽  
Vincent Sol
Keyword(s):  
Infrared Absorption ◽  
Near Infrared ◽  
Water Soluble ◽  
Design And Synthesis
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