Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

2011 ◽  
Vol 21 (21) ◽  
pp. 6608-6612 ◽  
Author(s):  
Jill M. Scott ◽  
Christopher Baccei ◽  
Gretchen Bain ◽  
Alex Broadhead ◽  
Jilly F. Evans ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
D2 Receptor ◽  
Prostaglandin D2 ◽  
Biphenylacetic Acid

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

2009 ◽  
Vol 19 (16) ◽  
pp. 4647-4651 ◽  
Author(s):  
Brian A. Stearns ◽  
Christopher Baccei ◽  
Gretchen Bain ◽  
Alex Broadhead ◽  
Ryan C. Clark ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
D2 Receptor ◽  
Prostaglandin D2

scholarly journals Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model

2021 ◽  
Vol 141 ◽  
pp. 111944
Author(s):  
Susanna Choi ◽  
Myung-A Jung ◽  
Youn-Hwan Hwang ◽  
Bo-Jeong Pyun ◽  
Joo Young Lee ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Asarum Heterotropoides

Site-specific sensitization in a murine model of allergic rhinitis: Role of the upper airway in lower airways disease

2002 ◽  
Vol 110 (6) ◽  
pp. 891-898 ◽  
Author(s):  
Christine McCusker ◽  
Martin Chicoine ◽  
Qutayba Hamid ◽  
Bruce Mazer
Keyword(s):  
Allergic Rhinitis ◽  
Murine Model ◽  
Upper Airway ◽  
Site Specific ◽  
Lower Airways

scholarly journals Treatment of COVID-19 pneumonia and acute respiratory distress with ramatroban, a thromboxane A2 and prostaglandin D2 receptor antagonist: A 4-Patient Case Series Report

2021 ◽  
Author(s):  
Martin L. Ogletree ◽  
Kate Chander Chiang ◽  
Rashmi Kulshreshta ◽  
Aditya Agarwal ◽  
Ashutosh Agarwal ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Organ Failure ◽  
Viral Infections ◽  
Pulmonary Veins ◽  
D2 Receptor ◽  
Case Series ◽  
Acute Onset ◽  
Lipid Mediator ◽  
Prostaglandin D2 ◽  
Th2 Immune Response

Abstract COVID-19 associated pneumonia and acute respiratory distress syndrome are characterized by a lipid mediator storm with massive increases in lung and systemic thromboxane A2 >> prostaglandin D2. Thromboxane A2 is a potent vasoconstrictor of pulmonary veins >> arteries, and thereby promotes an increase in pulmonary capillary pressures, transudation of fluid into the alveolar space, pulmonary edema and ARDS. Thromboxane A2 also increases vascular permeability, contracts bronchial smooth muscle, triggers and amplifies platelet activation, and promotes a prothrombotic state. PGD2 promotes a Th2 immune response that is atypical for viral infections and inhibits antiviral defense by suppressing interferon λ expression. D-dimers, urinary 11-dehydro-TxB2, and IL-13, a Th2 cytokine, have emerged as key biomarkers of severity and organ failure in COVID-19. Ramatroban is an orally bioavailable, potent, dual antagonist of the thromboxane A2 (TPr) and PGD2 (DPr2) receptors. We report use of ramatroban in 4 COVID-19 outpatients, 22 to 87 years of age, with acute onset / worsening of respiratory distress and hypoxemia. All four patients experienced decrease in respiratory distress and increase in SpO2, within hours of the first dose and thereby avoided hospitalization. By the 5th day all 4 patients had complete resolution of respiratory distress and hypoxemia. Ramatroban (Baynas®, Bayer Yakuhin Ltd., Japan) has an established safety profile, having been indicated in Japan for the treatment of allergic rhinitis for over 20 years. As a broncho-relaxant, anti-vasospastic, anti-thrombotic and immunomodulator, ramatroban addresses the fundamental pathophysiologic mechanisms underlying respiratory and critical organ failure in COVID-19, and therefore merits urgent clinical trials that might impact the ongoing pandemic.

Intranasal azelastine and mometasone exhibit a synergistic effect on a murine model of allergic rhinitis

2017 ◽  
Vol 38 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Do Hyun Kim ◽  
Boo-Young Kim ◽  
Ji-Hyeon Shin ◽  
Sung Won Kim ◽  
Soo Whan Kim
Keyword(s):  
Allergic Rhinitis ◽  
Synergistic Effect ◽  
Murine Model
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