Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies

2007 ◽  
Vol 17 (3) ◽  
pp. 668-672 ◽  
Author(s):  
Mei Liu ◽  
Sanyi Wang ◽  
Jill E. Clampit ◽  
Rebecca J. Gum ◽  
Deanna L. Haasch ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
New Class ◽  
Sar Studies

Synthesis and Initial SAR Studies of 3,6-Disubstituted Pyrazolo[1,5-a]pyrimidines: A New Class of KDR Kinase Inhibitors

2002 ◽  
Vol 12 (19) ◽  
pp. 2767-2770 ◽  
Author(s):  
Mark E. Fraley ◽  
William F. Hoffman ◽  
Robert S. Rubino ◽  
Randall W. Hungate ◽  
Andrew J. Tebben ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
New Class ◽  
Sar Studies

scholarly journals SAR Studies for a New Class of Antibacterial NAD Biosynthesis Inhibitors

2009 ◽  
Vol 11 (4) ◽  
pp. 617-625 ◽  
Author(s):  
Whitney Beysselance Moro ◽  
Zhengrong Yang ◽  
Tasha A. Kane ◽  
Qingxian Zhou ◽  
Steve Harville ◽  
...  
Keyword(s):  
New Class ◽  
Nad Biosynthesis ◽  
Sar Studies ◽  
Biosynthesis Inhibitors

scholarly journals Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease

2012 ◽  
Vol 12 (4) ◽  
pp. 464-470 ◽  
Author(s):  
Apostolos Kontzias ◽  
Alexander Kotlyar ◽  
Arian Laurence ◽  
Paul Changelian ◽  
John J O'Shea
Keyword(s):  
Autoimmune Disease ◽  
Kinase Inhibitors ◽  
New Class

scholarly journals Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2181 ◽  
Author(s):  
Florence Couly ◽  
Marine Harari ◽  
Carole Dubouilh-Benard ◽  
Laetitia Bailly ◽  
Emilie Petit ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Active Compounds ◽  
Sar Studies ◽  
Ic50 Values ◽  
Last Stage ◽  
Metal Catalyzed

Efficient metal catalyzed C–H arylation of 8-alkyl-thiazolo[5,4-f]-quinazolin-9-ones was explored for SAR studies. Application of this powerful chemical tool at the last stage of the synthesis of kinase inhibitors allowed the synthesis of arrays of molecules inspired by fragment-growing studies generated by molecular modeling calculations. Among the potentially active compounds designed through this strategy, FC162 (4c) exhibits nanomolar IC50 values against some kinases, and is the best candidate for the development as a DYRK kinase inhibitor.

ChemInform Abstract: Entry into a New Class of Protein Kinase Inhibitors by Pseudo Ring Design.

ChemInform ◽  
2008 ◽  
Vol 39 (27) ◽  
Author(s):  
Pascal Furet ◽  
Giorgio Caravatti ◽  
Vito Guagnano ◽  
Marc Lang ◽  
Thomas Meyer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
New Class

Tyrosine kinase inhibitors: New class of antimalarials on the horizon?

2015 ◽  
Vol 55 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Vrushali Pathak ◽  
Roshan Colah ◽  
Kanjaksha Ghosh
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Kinase Inhibitors ◽  
New Class
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