Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors

2006 ◽  
Vol 16 (21) ◽  
pp. 5616-5620 ◽  
Author(s):  
Namal C. Warshakoon ◽  
Shengde Wu ◽  
Angelique Boyer ◽  
Richard Kawamoto ◽  
Justin Sheville ◽  
...  
Keyword(s):  
Prolyl Hydroxylase ◽  
Pyridine Derivatives ◽  
Design And Synthesis

Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity

2015 ◽  
Vol 23 (1) ◽  
pp. 160-173 ◽  
Author(s):  
Tara Man Kadayat ◽  
Chanmi Park ◽  
Kyu-Yeon Jun ◽  
Til Bahadur Thapa Magar ◽  
Ganesh Bist ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Pyridine Derivatives ◽  
Design And Synthesis

Design and Synthesis of Piperazine‐Linked Imidazo[1,2‐ a ]pyridine Derivatives as Potent Anticancer Agents

2019 ◽  
Vol 4 (46) ◽  
pp. 13622-13629 ◽  
Author(s):  
Madhusudhana Reddy Gangireddy ◽  
Manohar Mantipally ◽  
Rambabu Gundla ◽  
Vishnu Nayak Badavath ◽  
Kalyani Paidikondala ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Pyridine Derivatives ◽  
Design And Synthesis

scholarly journals DESIGN AND SYNTHESIS OF NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR ANTI-BACTERIAL ACTIVITY

2018 ◽  
Vol 11 (8) ◽  
pp. 252 ◽  
Author(s):  
Pushpalatha Budumuru ◽  
Srinivasarao Golagani ◽  
Venkata Siva Satyanaryana Kantamreddi
Keyword(s):  
Antibacterial Activity ◽  
Dna Gyrase ◽  
Docking Studies ◽  
Beta Subunit ◽  
Diffusion Method ◽  
Pyridine Derivatives ◽  
Standard Drug ◽  
Mass Spectral ◽  
Design And Synthesis ◽  
Relationship Of

Objective: The present study aims to synthesize a novel derivatives of Imidazo[1,2-a]pyridines and the compounds were evaluated for their antibacterial activity.Methods: A series of newly synthesized compounds were characterized by 1H-nuclear magnetic resonance (NMR), 13C-NMR, Fourier transform infrared, mass spectral analysis, and screened for their antibacterial activity by disc diffusion method. Molecular docking studies were performed with a bacterial beta subunit of DNA gyrase using Auto Dock 4.2.6, and the docked conformations were analyzed using visual molecular dynamics.Results: The structural activity relationship of the synthesized imidazo[1,2-a]pyridine derivatives was studied against Gram-positive and Gram-negative bacteria. Among the synthesized compounds N-benzyl-4-((2-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl) acetamido)methyl) benzamide (9a) are possessing high activity against Bacillus subtilis. The zone of inhibition produced by the compound 9a is wider than that of remaining compounds used in this study.Conclusion: The synthesized compounds exhibited good antibacterial activity in comparison with standard drug streptomycin. This suggests that the compound 9a and its analogs are exerting their activity by probably inhibiting bacterial beta subunit of DNA gyrase.

A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors

2006 ◽  
Vol 16 (21) ◽  
pp. 5598-5601 ◽  
Author(s):  
Namal C. Warshakoon ◽  
Shengde Wu ◽  
Angelique Boyer ◽  
Richard Kawamoto ◽  
Justin Sheville ◽  
...  
Keyword(s):  
Prolyl Hydroxylase ◽  
Pyridine Derivatives

Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists

2016 ◽  
Vol 26 (15) ◽  
pp. 3441-3446 ◽  
Author(s):  
Daisuke Matsuda ◽  
Yohei Kobashi ◽  
Ayako Mikami ◽  
Madoka Kawamura ◽  
Fumiyasu Shiozawa ◽  
...  
Keyword(s):  
Pyridine Derivatives ◽  
Structural Class ◽  
Design And Synthesis

scholarly journals Structure-Based Design and Synthesis of New Estrane–Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors

2017 ◽  
Vol 8 (11) ◽  
pp. 1159-1164 ◽  
Author(s):  
Raphaël Dutour ◽  
Francisco Cortés-Benítez ◽  
Jenny Roy ◽  
Donald Poirier
Keyword(s):  
Cytochrome P450 ◽  
Pyridine Derivatives ◽  
Design And Synthesis

Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF

2020 ◽  
Vol 28 (11) ◽  
pp. 115493 ◽  
Author(s):  
Mohammed S. Abdel-Maksoud ◽  
Eslam M.H. Ali ◽  
Usama M. Ammar ◽  
Karim I. Mersal ◽  
Kyung Ho Yoo ◽  
...  
Keyword(s):  
Pyridine Derivatives ◽  
Design And Synthesis

Design and Synthesis of Novel Pyrimidine/Hexahydroquinazoline-Fused Pyrazolo[3,4-b]Pyridine Derivatives, Their Biological Evaluation and Docking Studies#

2019 ◽  
Vol 4 (1) ◽  
pp. 138-144 ◽  
Author(s):  
Mahajan Anuja Pradeep ◽  
Nagiri Ravi Kumar ◽  
Desireddy Krishna Swaroop ◽  
Narra Srikanth Reddy ◽  
Kanugala Sirisha ◽  
...  
Keyword(s):  
Docking Studies ◽  
Biological Evaluation ◽  
Pyridine Derivatives ◽  
Design And Synthesis
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