Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

2006 ◽  
Vol 16 (10) ◽  
pp. 2748-2752 ◽  
Author(s):  
Ester Muraglia ◽  
Olaf D. Kinzel ◽  
Ralph Laufer ◽  
Michael D. Miller ◽  
Gregory Moyer ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Hiv Reverse Transcriptase ◽  
Nucleoside Inhibitors

scholarly journals Uracil-Containing Heterodimers of a New Type: Synthesis and Study of Their Anti-Viral Properties

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3350
Author(s):  
Anna A. Maslova ◽  
Elena S. Matyugina ◽  
Robert Snoeck ◽  
Graciela Andrei ◽  
Sergey N. Kochetkov ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Reverse Transcriptase ◽  
Viral Infections ◽  
Virus Infections ◽  
Healthy Individuals ◽  
Type Synthesis ◽  
Hiv Reverse Transcriptase ◽  
Reverse Transcriptase Inhibitors ◽  
New Type ◽  
Nucleoside Inhibitors

Widespread latent herpes viral infections within a population can lead to the development of co-infections in HIV-infected patients. These infections are not particularly dangerous for healthy individuals and often occur with minimal symptoms, but for those who are immunocompromised, these infections can accelerate the acute phase of HIV infection and AIDS. Thus, the idea of designing compounds that could combine activity against HIV and co-infections would seem promising. In that regard, eleven compounds were synthesized that represent conjugates of non-nucleoside HIV reverse transcriptase inhibitors and nucleoside inhibitors of the herpes family viruses with the hope that these novel heterodimers will result in dual activity against HIV and concomitant herpes virus infections.

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

2008 ◽  
Vol 18 (15) ◽  
pp. 4348-4351 ◽  
Author(s):  
Zachary K. Sweeney ◽  
Sahaja Acharya ◽  
Andrew Briggs ◽  
James P. Dunn ◽  
Todd R. Elworthy ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Hiv Reverse Transcriptase ◽  
Nucleoside Inhibitors

Structure-activity evaluation of new uracil-based non-nucleoside inhibitors of HIV reverse transcriptase

MedChemComm ◽  
2013 ◽  
Vol 4 (11) ◽  
pp. 1443 ◽  
Author(s):  
Elena S. Matyugina ◽  
Vladimir T. Valuev-Elliston ◽  
Alexander N. Geisman ◽  
Mikhail S. Novikov ◽  
Alexander O. Chizhov ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Hiv Reverse Transcriptase ◽  
Activity Evaluation ◽  
Structure Activity ◽  
Nucleoside Inhibitors
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