Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors

2017 ◽  
Vol 25 (2) ◽  
pp. 609-620 ◽  
Author(s):  
S.N.C. Sridhar ◽  
George Ginson ◽  
P.O. Venkataramana Reddy ◽  
Mukund P. Tantak ◽  
Dalip Kumar ◽  
...  
Keyword(s):  
Pancreatic Lipase ◽  
Molecular Modelling ◽  
New Class ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Pancreatic Lipase Inhibitors

Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors

2020 ◽  
Vol 44 (28) ◽  
pp. 12355-12369
Author(s):  
Sridhar S. N. C. ◽  
Saksham Palawat ◽  
Atish T. Paul
Keyword(s):  
Pancreatic Lipase ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Pancreatic Lipase Inhibitors ◽  
Pancreatic Lipase Inhibition ◽  
Lipase Inhibition

Twenty-one indolyl oxoacetamides were designed and synthesized inspired by conophylline. Analogues 12c and 12b with N-geranyl substitution on indole exhibited potent pancreatic lipase inhibition.

Recreational drugs 25I-NBOH and 25I-NBOMe bind to both Sudlow's sites I and II of Human Serum Albumin (HSA): Biophysical and molecular modeling studies

2021 ◽  
Author(s):  
Wellington Alves de Barros ◽  
Marina de Magalhães Silva ◽  
Maria Dayanne de Araújo Dantas ◽  
Josue Santos ◽  
Isis Figueiredo ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Molecular Modelling ◽  
Recreational Drugs ◽  
Modeling Studies ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Molecular Modeling Studies

Experimental, biophysical, and molecular modelling studies between 25I-NBOH and 25I-NBOMe with human serum albumin (HSA) have indicated that these recreational drugs simultaneously bind to site I and II of the...

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