Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein

2014 ◽  
Vol 22 (7) ◽  
pp. 2311-2319 ◽  
Author(s):  
Zahida Parveen ◽  
Gerda Brunhofer ◽  
Ishrat Jabeen ◽  
Thomas Erker ◽  
Peter Chiba ◽  
...  
Keyword(s):  
3D Qsar ◽  
Biological Evaluation ◽  
Qsar Studies ◽  
Chalcone Derivatives ◽  
P Glycoprotein

scholarly journals Development of modulators of multidrug resistance: A pharmacoinformatic approach

2004 ◽  
Vol 76 (5) ◽  
pp. 997-1005 ◽  
Author(s):  
G. F. Ecker ◽  
Peter Chiba
Keyword(s):  
Neural Networks ◽  
Multidrug Resistance ◽  
Molecular Basis ◽  
Tumor Therapy ◽  
3D Qsar ◽  
Drug Efflux ◽  
Qsar Studies ◽  
P Glycoprotein ◽  
Drug Efflux Pumps ◽  
2D And 3D

Inhibition of drug efflux pumps such as P-glycoprotein represents a versatile approach for overcoming multidrug resistance in tumor therapy. Although numerous compounds have been identified as being able to inhibit P-glycoprotein, only little is known on the molecular basis of the drug–protein interaction. This article gives an overview of the different pharmacoinformatic approaches we used to develop new propafenone-type modulators of P-glycoprotein. These include 2D-and 3D-QSAR studies, artificial neural networks, and photoaffinity labeling studies.

Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors

2013 ◽  
Vol 23 (4) ◽  
pp. 1091-1095 ◽  
Author(s):  
Yin Luo ◽  
Shuai Zhang ◽  
Ke-Ming Qiu ◽  
Zhi-Jun Liu ◽  
Yu-Shun Yang ◽  
...  
Keyword(s):  
3D Qsar ◽  
Biological Evaluation ◽  
Pyrazole Derivatives ◽  
Qsar Studies ◽  
Telomerase Inhibitors

scholarly journals Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

2011 ◽  
Vol 19 (6) ◽  
pp. 2030-2045 ◽  
Author(s):  
Horrick Sharma ◽  
Shivaputra Patil ◽  
Tino W. Sanchez ◽  
Nouri Neamati ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
3D Qsar ◽  
Biological Evaluation ◽  
Integrase Inhibitors ◽  
Qsar Studies ◽  
Hiv 1

scholarly journals Modification, Biological Evaluation and 3D QSAR Studies of Novel 2-(1,3-Diaryl- 4,5-Dihydro-1H-Pyrazol-5-yl)Phenol Derivatives as Inhibitors of B-Raf Kinase

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e95702 ◽  
Author(s):  
Yu-Shun Yang ◽  
Fei Zhang ◽  
Dan-Jie Tang ◽  
Yong-Hua Yang ◽  
Hai-Liang Zhu
Keyword(s):  
3D Qsar ◽  
Biological Evaluation ◽  
Qsar Studies ◽  
Raf Kinase ◽  
Phenol Derivatives

Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents

2015 ◽  
Vol 93 ◽  
pp. 291-299 ◽  
Author(s):  
Shu-Fu Wang ◽  
Yong Yin ◽  
Ya-Liang Zhang ◽  
Shan-Wei Mi ◽  
Meng-Yue Zhao ◽  
...  
Keyword(s):  
3D Qsar ◽  
Biological Evaluation ◽  
Qsar Studies

Isolation, biological evaluation and 3D-QSAR studies of insecticidal/narcotic sesquiterpene polyol esters

2010 ◽  
Vol 17 (4) ◽  
pp. 681-693 ◽  
Author(s):  
Shao-peng Wei ◽  
Zhi-qin Ji ◽  
Hui-xiao Zhang ◽  
Ji-wen Zhang ◽  
Yong-hua Wang ◽  
...  
Keyword(s):  
3D Qsar ◽  
Biological Evaluation ◽  
Qsar Studies ◽  
Polyol Esters
Sign in / Sign up

Export Citation Format

Share Document