Structure–activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation

2011 ◽  
Vol 19 (24) ◽  
pp. 7711-7719 ◽  
Author(s):  
M. Vijaya Bhaskar Reddy ◽  
Wei-Jern Tsai ◽  
Keduo Qian ◽  
Kuo-Hsiung Lee ◽  
Tian-Shung Wu
Keyword(s):  
Platelet Aggregation ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Potential Inhibitors

scholarly journals Structure-activity relationships of novel 3-acylpyrrole derivatives: New inhibitors of platelet aggregation.

1980 ◽  
Vol 3 (11) ◽  
pp. 589-602
Author(s):  
AKIRA OHTSU ◽  
TOSHIO TANAKA ◽  
FUKUYOSHI KAMIMOTO ◽  
KENJI HOSHINA ◽  
SEIZI KUROZUMI ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Structure Activity Relationships ◽  
Structure Activity

New 4-Acyl-1-phenylaminocarbonyl-2-phenylpiperazine Derivatives as Potential Inhibitors of Adenovirus Infection. Synthesis, Biological Evaluation, and Structure–activity Relationships

2016 ◽  
Vol 59 (11) ◽  
pp. 5432-5448 ◽  
Author(s):  
Javier Sánchez-Céspedes ◽  
Pablo Martínez-Aguado ◽  
Margarita Vega-Holm ◽  
Ana Serna-Gallego ◽  
José Ignacio Candela ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Adenovirus Infection ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Potential Inhibitors

Preparation and antiplatelet activity of glycidic acid derivatives

2008 ◽  
Vol 62 (3) ◽  
Author(s):  
Josef Jampílek ◽  
Eliška Brojerová ◽  
Martin Doležal ◽  
Jiří Kuneš ◽  
Daniel Jun
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Chemical Structure ◽  
Biological Effects ◽  
Synthetic Approach ◽  
Antiplatelet Activity ◽  
Structure Activity ◽  
Standard Structure ◽  
Darzens Condensation ◽  
Potential Inhibitors

AbstractArylalkanoic acid derivatives exhibit a variety of biological effects. In the current publication some of new glycidic acid derivatives were prepared via the Darzens condensation. The synthetic approach, analytical and spectroscopic data of all newly synthesized compounds are presented. The prepared compounds were evaluated as potential inhibitors of arachidonic acid-induced platelet aggregation and their activity was compared with that of acetylsalicylic acid as the standard. (±)-Ethyl 3-{4-[(4-methoxyphenyl)sulfanyl]phenyl}-3-methyl-cis-oxirane-2-carboxylate (IC50 = 0.07 mmol L−1) and (±)-3-{4-[(4-methoxyphenyl)sulfanyl]phenyl}-3-methyl-cis-oxirane-2-carboxylic acid (IC50 = 0.06 mmol L−1) showed the highest antiplatelet activity against arachidonic acid-induced platelet aggregation comparable with the standard. Structure-activity relationships between the chemical structure, lipophilicity, and the antiplatelet activity of the evaluated compounds are discussed.

scholarly journals Aminopyrazolo[1,5-a]pyrimidines as potential inhibitors of Mycobacterium tuberculosis: Structure activity relationships and ADME characterization

2015 ◽  
Vol 23 (22) ◽  
pp. 7240-7250 ◽  
Author(s):  
Candice Soares de Melo ◽  
Tzu-Shean Feng ◽  
Renier van der Westhuyzen ◽  
Richard K. Gessner ◽  
Leslie J. Street ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Potential Inhibitors
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