Design, synthesis, and structure–activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

Surya K. De; Elisa Barile; Vida Chen; John L. Stebbins; Jason F. Cellitti; Thomas Machleidt; Coby B. Carlson; Li Yang; Russell Dahl; Maurizio Pellecchia

doi:10.1016/j.bmc.2011.03.017

Design, synthesis, and structure–activity relationship studies of thiophene-3-carboxamide derivatives as dual inhibitors of the c-Jun N-terminal kinase

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.03.017 ◽

2011 ◽

Vol 19 (8) ◽

pp. 2582-2588 ◽

Cited By ~ 9

Author(s):

Surya K. De ◽

Elisa Barile ◽

Vida Chen ◽

John L. Stebbins ◽

Jason F. Cellitti ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Dual Inhibitors

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Design, Synthesis, and Structure–Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00561 ◽

2020 ◽

Vol 63 (20) ◽

pp. 11498-11521

Author(s):

Kerstin Hiesinger ◽

Jan S. Kramer ◽

Sandra Beyer ◽

Timon Eckes ◽

Steffen Brunst ◽

...

Keyword(s):

Epoxide Hydrolase ◽

Soluble Epoxide Hydrolase ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Dual Inhibitors

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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Medicinal Chemistry ◽

10.2174/1573406412666151109113007 ◽

2016 ◽

Vol 12 (4) ◽

pp. 338-346 ◽

Cited By ~ 2

Author(s):

Yan Xia ◽

Qiong Duan ◽

Bao-Hua Zhao ◽

Dong-Feng Li ◽

Rui-Bin Hou

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104704 ◽

2021 ◽

Vol 109 ◽

pp. 104704

Author(s):

Ismail M.M. Othman ◽

Mohamed A.M. Gad-Elkareem ◽

El Hassane Anouar ◽

Kaïss Aouadi ◽

Mejdi Snoussi ◽

...

Keyword(s):

Molecular Docking ◽

Structure Activity Relationship ◽

Trna Synthetase ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Sar Analysis

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Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm980410m ◽

1998 ◽

Vol 41 (24) ◽

pp. 4819-4832 ◽

Cited By ~ 183

Author(s):

Simon Feldbæk Nielsen ◽

Søren Brøgger Christensen ◽

Gabriele Cruciani ◽

Arsalan Kharazmi ◽

Tommy Liljefors

Keyword(s):

Three Dimensional ◽

Statistical Design ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity

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Novel Pyrazole-4-acetohydrazide Derivatives Potentially Targeting Fungal Succinate Dehydrogenase: Design, Synthesis, Three-Dimensional Quantitative Structure–Activity Relationship, and Molecular Docking

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.1c03399 ◽

2021 ◽

Author(s):

Xiaobin Wang ◽

Mengqi Wang ◽

Ling Han ◽

Fei Jin ◽

Jian Jiao ◽

...

Keyword(s):

Molecular Docking ◽

Succinate Dehydrogenase ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.10.037 ◽

2015 ◽

Vol 89 ◽

pp. 21-31 ◽

Cited By ~ 26

Author(s):

Ayyiliath M. Sajith ◽

K.K. Abdul Khader ◽

Nithin Joshi ◽

Manchala Nageswar Reddy ◽

M. Syed Ali Padusha ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cytotoxic Agents ◽

Activity Relationship ◽

Design Synthesis ◽

Sar Studies ◽

Structure Activity

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New carboxamide derivatives bearing benzenesulphonamide as a selective COX-II inhibitor: Design, synthesis and structure-activity relationship

PLoS ONE ◽

10.1371/journal.pone.0183807 ◽

2017 ◽

Vol 12 (9) ◽

pp. e0183807 ◽

Cited By ~ 3

Author(s):

David Izuchukwu Ugwu ◽

Uchechukwu Chris Okoro ◽

Hilal Ahmad

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Inhibitor Design ◽

Design Synthesis ◽

Structure Activity

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Design, Synthesis and Quantitative Structure-Activity Relationship Study of N-(3-Oxo-3,4-dihydro-2H-benzo(1,4)oxazine-7-carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1975 ◽

1997 ◽

Vol 45 (12) ◽

pp. 1975-1983 ◽

Cited By ~ 3

Author(s):

Takeshi YAMAMOTO ◽

Manabu HORI ◽

Ikuo WATANABE ◽

Hisayoshi TSUTSUI ◽

Kengo HARADA ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Guanidine Derivatives ◽

Structure Activity ◽

Relationship Study

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Design, synthesis and structure–activity relationship of simple bis-amides as potent inhibitors of GlyT1

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2008.09.005 ◽

2008 ◽

Vol 18 (20) ◽

pp. 5533-5536 ◽

Cited By ~ 11

Author(s):

Synèse Jolidon ◽

Daniela Alberati ◽

Adam Dowle ◽

Holger Fischer ◽

Dominik Hainzl ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of

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