Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: Design, synthesis, and structure–activity relationships

2010 ◽  
Vol 18 (21) ◽  
pp. 7675-7699 ◽  
Author(s):  
Shigeo Hayashi ◽  
Eriko Nakata ◽  
Asato Morita ◽  
Kunihiko Mizuno ◽  
Kenzo Yamamura ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Orphanin Fq ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Peptide Agonist

Design, Synthesis, and Structure−Activity Relationships of Benzophenone-Based Tetraamides as Novel Antibacterial Agents

2009 ◽  
Vol 52 (16) ◽  
pp. 5020-5031 ◽  
Author(s):  
Sunil K. Vooturi ◽  
Chrissy M. Cheung ◽  
Michael J. Rybak ◽  
Steven M. Firestine
Keyword(s):  
Antibacterial Agents ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Pyrazole-Based Acid Ceramidase Inhibitors: Design, Synthesis, and Structure–Activity Relationships

Synthesis ◽  
2016 ◽  
Vol 48 (17) ◽  
pp. 2739-2756 ◽  
Author(s):  
Daniele Piomelli ◽  
Eleonora Diamanti ◽  
Giovanni Bottegoni ◽  
Luca Goldoni ◽  
Natalia Realini ◽  
...  
Keyword(s):  
Acid Ceramidase ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

2020 ◽  
Vol 44 (6) ◽  
pp. 2247-2255
Author(s):  
Qifan Zhou ◽  
Lina Jia ◽  
Fangyu Du ◽  
Xiaoyu Dong ◽  
Wanyu Sun ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Activity Assay ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Enhancer Of Zeste

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

Design, synthesis, and structure–activity relationships of indole-3-heterocycles as agonists of the CB1 receptor

2011 ◽  
Vol 21 (1) ◽  
pp. 506-509 ◽  
Author(s):  
Angus J. Morrison ◽  
Julia M. Adam ◽  
James A. Baker ◽  
Robert A. Campbell ◽  
John K. Clark ◽  
...  
Keyword(s):  
Cb1 Receptor ◽  
Design Synthesis ◽  
Structure Activity Relationships ◽  
Structure Activity
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