Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector

2007 ◽  
Vol 15 (4) ◽  
pp. 1708-1715 ◽  
Author(s):  
Hyun Jin Kim ◽  
Min Sung Kwon ◽  
Joon Sig Choi ◽  
Bo Hye Kim ◽  
Jae Keun Yoon ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Synthesis And Characterization ◽  
Amino Ester ◽  
Gene Delivery Vector ◽  
Delivery Vector

Synthesis and characterization of Poly(L-lysine-co-L-proline) as a non-viral gene delivery vector

2006 ◽  
Vol 14 (2) ◽  
pp. 129-131 ◽  
Author(s):  
Soo-Jeong Lee ◽  
Cheol-Hee Ahn ◽  
Jeong Hoon Ko ◽  
Su Young Chae ◽  
Minhyung Lee
Keyword(s):  
Gene Delivery ◽  
Synthesis And Characterization ◽  
Viral Gene ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

In Vitro Design and Characterization of the Nonviral Gene Delivery Vector Iopamidol, Protamine, Ethiodized Oil Reagent

2011 ◽  
Vol 22 (10) ◽  
pp. 1457-1463.e2 ◽  
Author(s):  
Luke J. Higgins ◽  
Gloria L. Hwang ◽  
Jarrett Rosenberg ◽  
Regina H. Katzenberg ◽  
Nishita Kothary ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Gene Delivery ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Ethiodized Oil

Biophysical Characterization of an Integrin-Targeted Lipopolyplex Gene Delivery Vector†

Biochemistry ◽  
2007 ◽  
Vol 46 (45) ◽  
pp. 12930-12944 ◽  
Author(s):  
M. Firouz Mohd Mustapa ◽  
Paul C. Bell ◽  
Christopher A. Hurley ◽  
Alastair Nicol ◽  
Erwann Guénin ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Biophysical Characterization ◽  
Gene Delivery Vector ◽  
Delivery Vector

scholarly journals Biophysical Characterization of an Integrin-Targeted Lipopolyplex Gene Delivery Vector

Biochemistry ◽  
2006 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
P.C. Bell ◽  
C.A. Hurley ◽  
A. Nicol ◽  
E. Guenin ◽  
J.B. Wong ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Biophysical Characterization ◽  
Gene Delivery Vector ◽  
Delivery Vector

Characterization of the human dynein light chain Rp3 and its use as a non-viral gene delivery vector

2013 ◽  
Vol 98 (8) ◽  
pp. 3591-3602 ◽  
Author(s):  
M. A. S. Toledo ◽  
M. T. P. Favaro ◽  
R. F. Alves ◽  
C. A. Santos ◽  
L. L. Beloti ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Light Chain ◽  
Viral Gene ◽  
Dynein Light Chain ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Viral Gene Delivery

Exosome as a Natural Gene Delivery Vector for Cancer Treatment

2020 ◽  
Vol 20 (11) ◽  
pp. 821-830
Author(s):  
Prasad Pofali ◽  
Adrita Mondal ◽  
Vaishali Londhe
Keyword(s):  
Gene Therapy ◽  
Gene Delivery ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Intestinal Barrier ◽  
Gene Carrier ◽  
Gene Delivery Vector ◽  
Delivery Vector

Background: Current gene therapy vectors such as viral, non-viral, and bacterial vectors, which are used for cancer treatment, but there are certain safety concerns and stability issues of these conventional vectors. Exosomes are the vesicles of size 40-100 nm secreted from multivesicular bodies into the extracellular environment by most of the cell types in-vivo and in-vitro. As a natural nanocarrier, exosomes are immunologically inert, biocompatible, and can cross biological barriers like the blood-brain barrier, intestinal barrier, and placental barrier. Objective: This review focusses on the role of exosome as a carrier to efficiently deliver a gene for cancer treatment and diagnosis. The methods for loading of nucleic acids onto the exosomes, advantages of exosomes as a smart intercellular shuttle for gene delivery and therapeutic applications as a gene delivery vector for siRNA, miRNA and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and also the limitations of exosomes as a gene carrier are all reviewed in this article. Methods: Mostly, electroporation and chemical transfection are used to prepare gene loaded exosomes. Results: Exosome-mediated delivery is highly promising and advantageous in comparison to the current delivery methods for systemic gene therapy. Targeted exosomes, loaded with therapeutic nucleic acids, can efficiently promote the reduction of tumor proliferation without any adverse effects. Conclusion: In the near future, exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer.

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