Stereocontrolled synthesis of anticancer β-lactams via the Staudinger reaction

2005 ◽  
Vol 13 (11) ◽  
pp. 3611-3622 ◽  
Author(s):  
Bimal K. Banik ◽  
Indrani Banik ◽  
Frederick F. Becker
Keyword(s):  
Staudinger Reaction ◽  
Stereocontrolled Synthesis

ChemInform Abstract: Stereocontrolled Synthesis of β-Lactams via Staudinger Reaction Between Phenoxyketenes and Chiral Imines.

ChemInform ◽  
2010 ◽  
Vol 33 (19) ◽  
pp. no-no
Author(s):  
Seema Kanwar ◽  
Aarti Saluja ◽  
J. P. S. Khurana ◽  
S. D. Sharma
Keyword(s):  
Staudinger Reaction ◽  
Stereocontrolled Synthesis ◽  
Chiral Imines

Stereocontrolled synthesis of tetrahydrofurans and tetrahydropyrans using thallium(III)-induced cyclizations

1985 ◽  
Vol 50 (14) ◽  
pp. 2416-2423 ◽  
Author(s):  
Joseph P. Michael ◽  
Pauline C. Ting ◽  
Paul A. Bartlett
Keyword(s):  
Stereocontrolled Synthesis

scholarly journals Solid-Phase Stereocontrolled Synthesis of Oligomeric P-Modified Glycosyl Phosphate Derivatives Using the Oxazaphospholidine Method

ACS Omega ◽  
2021 ◽  
Author(s):  
Kazuki Sato ◽  
Tomoya Hagio ◽  
Michi Sano ◽  
Kazumasa Muramoto ◽  
Aya Yaoita ◽  
...  
Keyword(s):  
Solid Phase ◽  
Stereocontrolled Synthesis ◽  
Glycosyl Phosphate

ChemInform Abstract: A Facile and Stereocontrolled Synthesis of syn-α-Alkyl α-Hydroxy β-Amino Acids.

ChemInform ◽  
2010 ◽  
Vol 31 (5) ◽  
pp. no-no
Author(s):  
Alessandra Maria Nocioni ◽  
Carmela Papa ◽  
Claudia Tomasini
Keyword(s):  
Amino Acids ◽  
Stereocontrolled Synthesis

scholarly journals Metal-Free Air Oxidation in a Convenient Cascade Approach for the Access to Isoquinoline-1,3,4(2H)-triones

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2177
Author(s):  
Antonia Di Mola ◽  
Consiglia Tedesco ◽  
Antonio Massa
Keyword(s):  
Heterocyclic Compounds ◽  
Aromatic Ketone ◽  
Primary Amines ◽  
Cascade Process ◽  
Staudinger Reaction ◽  
Caspase Inhibitor ◽  
Air Oxidation ◽  
Metal Free ◽  
Free Air

Herein we describe a very useful application of the readily available trifunctional aromatic ketone methyl-2-(2-bromoacetyl)benzoate in reactions with primary amines. An unexpected in situ air oxidation that follows a cascade process allowed the access to a series of isoquinoline-1,3,4(2H)-triones, a class of heterocyclic compounds of great interest containing an oxygen-rich heterocyclic scaffold. A modification of the original protocol, utilizing a Staudinger reaction in the presence of trimethylphosphine, was necessary for the synthesis of Caspase inhibitor trione with free NH group.

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