Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases

Xiangdong Su; Harshani Lawrence; Dharshini Ganeshapillai; Adrian Cruttenden; Atul Purohit; Michael J Reed; Nigel Vicker; Barry V.L Potter

doi:10.1016/j.bmc.2004.06.008

Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.06.008 ◽

2004 ◽

Vol 12 (16) ◽

pp. 4439-4457 ◽

Cited By ~ 42

Author(s):

Xiangdong Su ◽

Harshani Lawrence ◽

Dharshini Ganeshapillai ◽

Adrian Cruttenden ◽

Atul Purohit ◽

...

Keyword(s):

Glycyrrhetinic Acid ◽

Selective Inhibitors ◽

Hydroxysteroid Dehydrogenases

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Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.02.020 ◽

2016 ◽

Vol 112 ◽

pp. 280-288 ◽

Cited By ~ 47

Author(s):

Li-Wei Zou ◽

Yao-Guang Li ◽

Ping Wang ◽

Kun Zhou ◽

Jie Hou ◽

...

Keyword(s):

Structure Activity Relationship ◽

Glycyrrhetinic Acid ◽

Activity Relationship ◽

Selective Inhibitors ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Relative involvement of three 17β-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors

Molecular and Cellular Endocrinology ◽

10.1016/j.mce.2008.08.026 ◽

2009 ◽

Vol 301 (1-2) ◽

pp. 146-153 ◽

Cited By ~ 46

Author(s):

Yannick Laplante ◽

Claudine Rancourt ◽

Donald Poirier

Keyword(s):

Breast Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Cancer Cell Lines ◽

Breast Cancer Cell Lines ◽

Selective Inhibitors ◽

Hydroxysteroid Dehydrogenases

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11β-Hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances

Steroids ◽

10.1016/0039-128x(95)00201-z ◽

1996 ◽

Vol 61 (3) ◽

pp. 110-115 ◽

Cited By ~ 27

Author(s):

Elise P. Gomez-Sanchez ◽

Diana Cox ◽

Mark Foecking ◽

Venkataseshu Ganjam ◽

Celso E. Gomez-Sanchez

Keyword(s):

Cell Line ◽

Glycyrrhetinic Acid ◽

Natural Substances ◽

Hydroxysteroid Dehydrogenases ◽

Choriocarcinoma Cell Line

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The effects of the licorice derivative, glycyrrhetinic acid, on hepatic 3α- and 3β-hydroxysteroid dehydrogenases and 5α- and 5β-reductase pathways of metabolism of aldosterone in male rats

Steroids ◽

10.1016/0039-128x(90)90024-6 ◽

1990 ◽

Vol 55 (2) ◽

pp. 52-58 ◽

Cited By ~ 73

Author(s):

Syed A. Latif ◽

Tammy J. Conca ◽

David J. Morris

Keyword(s):

Glycyrrhetinic Acid ◽

Male Rats ◽

Hydroxysteroid Dehydrogenases

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Evaluation of selective inhibitors of histone deacetylases as potential neurotrophic agents

Planta Medica ◽

10.1055/s-0035-1545184 ◽

2015 ◽

Vol 81 (05) ◽

Author(s):

S Shukla ◽

I Muhammad ◽

LA Walker ◽

BL Tekwani

Keyword(s):

Histone Deacetylases ◽

Selective Inhibitors

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Natural and synthetic indirubins as potent and selective inhibitors of the protozoan parasite Leishmania donovani

Planta Medica ◽

10.1055/s-2007-987162 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

E Xingi ◽

D Smirlis ◽

S Bisti ◽

V Myrianthopoulos ◽

P Magiatis ◽

...

Keyword(s):

Leishmania Donovani ◽

Protozoan Parasite ◽

Selective Inhibitors ◽

Parasite Leishmania ◽

Natural And Synthetic

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Faculty Opinions recommendation of Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1008829.113110 ◽

2002 ◽

Author(s):

Thomas W von Geldern

Keyword(s):

Hydroxysteroid Dehydrogenase ◽

Antidiabetic Drugs ◽

Selective Inhibitors ◽

New Class

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Faculty Opinions recommendation of Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1018044.207595 ◽

2004 ◽

Author(s):

Wolfgang Jahnke

Keyword(s):

Structure Function ◽

Hydroxysteroid Dehydrogenases

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Faculty Opinions recommendation of Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10242.467735 ◽

2006 ◽

Author(s):

Raymond DuBois

Keyword(s):

Interindividual Variability ◽

Cyclooxygenase 2 ◽

Selective Inhibitors

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Faculty Opinions recommendation of Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1160078.620349 ◽

2009 ◽

Author(s):

Michal Lebl ◽

Petr Capek

Keyword(s):

High Throughput ◽

High Throughput Screening ◽

Selective Inhibitors

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