Design, synthesis and biological activity of amidinobicyclic compounds (derivatives of DX-9065a) as factor Xa inhibitors: SAR study of S1 and aryl binding sites

2004 ◽  
Vol 12 (9) ◽  
pp. 2099-2114 ◽  
Author(s):  
Satoshi Komoriya ◽  
Naoaki Kanaya ◽  
Takayasu Nagahara ◽  
Asako Yokoyama ◽  
Kazue Inamura ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Sites ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Sar Study ◽  
Derivatives Of

Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites

2005 ◽  
Vol 13 (12) ◽  
pp. 3927-3954 ◽  
Author(s):  
Satoshi Komoriya ◽  
Noriyasu Haginoya ◽  
Shozo Kobayashi ◽  
Tsutomu Nagata ◽  
Akiyoshi Mochizuki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Binding Sites ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Basic Compounds ◽  
Sar Study

Design, synthesis, and in vitro biological activity of benzimidazole based factor Xa inhibitors

2000 ◽  
Vol 10 (9) ◽  
pp. 963-966 ◽  
Author(s):  
Zuchun (Spring) Zhao ◽  
Damian O Arnaiz ◽  
Brian Griedel ◽  
Steven Sakata ◽  
Jerry L Dallas ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis

Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units

2004 ◽  
Vol 12 (21) ◽  
pp. 5579-5586 ◽  
Author(s):  
Noriyasu Haginoya ◽  
Syozo Kobayashi ◽  
Satoshi Komoriya ◽  
Toshiharu Yoshino ◽  
Tsutomu Nagata ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis

Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines††See ref. 1.

2002 ◽  
Vol 10 (3) ◽  
pp. 657-666 ◽  
Author(s):  
Howard P. Ng ◽  
Brad O. Buckman ◽  
Keith A. Eagen ◽  
William J. Guilford ◽  
Monica J. Kochanny ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis

Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors

2000 ◽  
Vol 10 (9) ◽  
pp. 957-961 ◽  
Author(s):  
Damian O Arnaiz ◽  
Zuchun (Spring) Zhao ◽  
Amy Liang ◽  
Lan Trinh ◽  
Marc Whitlow ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis

Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template

2003 ◽  
Vol 11 (3) ◽  
pp. 367-381 ◽  
Author(s):  
Fukushi Hirayama ◽  
Hiroyuki Koshio ◽  
Naoko Katayama ◽  
Tsukasa Ishihara ◽  
Hiroyuki Kaizawa ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Orally Bioavailable

Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification

2006 ◽  
Vol 14 (5) ◽  
pp. 1309-1330 ◽  
Author(s):  
Satoshi Komoriya ◽  
Shozo Kobayashi ◽  
Ken Osanai ◽  
Toshiharu Yoshino ◽  
Tsutomu Nagata ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Metabolic Stability ◽  
Factor Xa Inhibitors ◽  
Design Synthesis ◽  
Ligand Modification

ChemInform Abstract: Design, Synthesis, and in Vitro Biological Activity of Indole-Based Factor Xa Inhibitors.

ChemInform ◽  
2010 ◽  
Vol 31 (35) ◽  
pp. no-no
Author(s):  
Damian O. Arnaiz ◽  
Zuchun Zhao ◽  
Amy Liang ◽  
Lan Trinh ◽  
Marc Whitlow ◽  
...  
Keyword(s):  
Biological Activity ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Design Synthesis
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