Late results following flap reconstruction for chest wall recurrent breast cancer

2013 ◽  
Vol 66 (2) ◽  
pp. 165-173 ◽  
Author(s):  
A.J. Lindford ◽  
T.A. Jahkola ◽  
E. Tukiainen
Keyword(s):  
Breast Cancer ◽  
Chest Wall ◽  
Recurrent Breast Cancer ◽  
Late Results ◽  
Flap Reconstruction ◽  
Recurrent Breast

scholarly journals Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study

2018 ◽  
Vol 36 (13) ◽  
pp. 1317-1322 ◽  
Author(s):  
Reshma Jagsi ◽  
Kent A. Griffith ◽  
Jennifer R. Bellon ◽  
Wendy A. Woodward ◽  
Janet K. Horton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Phase I ◽  
Chest Wall ◽  
Clinical Investigation ◽  
Recurrent Breast Cancer ◽  
Regional Lymph Nodes ◽  
Moist Desquamation ◽  
Grade 3 ◽  
Recurrent Breast

Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety. Patients and Methods We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recurrent breast cancer after complete surgical resection. RT consisted of 50 Gy to the chest wall and regional lymph nodes plus a 10-Gy boost. A Bayesian time-to-event continual reassessment method escalated dose through four levels, with a 30% targeted rate of dose-limiting toxicity (DLT) measured during the 6 weeks of treatment plus 4 weeks of follow-up. DLTs were defined as confluent moist desquamation > 100 cm2, nonhematologic toxicity grade ≥ 3, toxicity that requires an RT dose delay > 1 week, absolute neutrophil count < 1,000/mm3, platelet count < 50,000/mm3, or hemoglobin < 8.0 g/dL if possibly, probably, or definitely related to study treatment. Results Five DLTs occurred: Four were moist desquamation (two each at 100 and 150 mg twice a day), and one was neutropenia (at 200 mg twice a day). The crude rate of any grade 3 toxicity (regardless of attribution) was 10% at year 1, 16.7% at year 2, and 46.7% at year 3. At year 3, six of 15 surviving patients had severe fibrosis in the treatment field. Conclusion Although severe acute toxicity did not exceed 30% even at the highest tested dose, nearly half of surviving patients demonstrated grade 3 adverse events at 3 years, which underscores the importance of long-term monitoring of toxicity in trials of radiosensitizing agents.

MR imaging demonstration of a recurrent breast cancer following deep inferior epigastric perforator (DIEP) flap reconstruction

2006 ◽  
Vol 59 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Caroline Caramella ◽  
Alain Luciani ◽  
Thu Ha Dao ◽  
Laurent Lantieri ◽  
Laurent Zelek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Recurrent Breast Cancer ◽  
Diep Flap ◽  
Flap Reconstruction ◽  
Deep Inferior Epigastric Perforator ◽  
Recurrent Breast

Chest wall resection for locally recurrent breast cancer: Indications, technique, and results

1992 ◽  
Vol 49 (3) ◽  
pp. 189-195 ◽  
Author(s):  
Steven T. Brower ◽  
Hubert Weinberg ◽  
Paul I. Tartter ◽  
Jorge Camunas
Keyword(s):  
Breast Cancer ◽  
Chest Wall ◽  
Recurrent Breast Cancer ◽  
Chest Wall Resection ◽  
Locally Recurrent ◽  
Recurrent Breast

Full-Thickness Resection With Myocutaneous Flap Reconstruction for Locally Recurrent Breast Cancer

2008 ◽  
Vol 85 (6) ◽  
pp. 1894-1900 ◽  
Author(s):  
Godehard Friedel ◽  
Thomas Kuipers ◽  
Jürgen Dippon ◽  
Fawaz Al-Kammash ◽  
Thorsten Walles ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Myocutaneous Flap ◽  
Recurrent Breast Cancer ◽  
Full Thickness ◽  
Flap Reconstruction ◽  
Locally Recurrent ◽  
Recurrent Breast

scholarly journals Chest-Wall Resection for Locally Recurrent Breast Cancer

1969 ◽  
Vol 19 (5) ◽  
pp. 282-288 ◽  
Author(s):  
A. F. Snyder ◽  
G. M. Farrow ◽  
J. K. Masson ◽  
W. S. Payne
Keyword(s):  
Breast Cancer ◽  
Chest Wall ◽  
Recurrent Breast Cancer ◽  
Chest Wall Resection ◽  
Locally Recurrent ◽  
Recurrent Breast
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