scholarly journals Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case–control studies

2016 ◽  
Vol 20 (6) ◽  
pp. 605-609 ◽  
Author(s):  
Hamidreza Majidiani ◽  
Sahar Dalvand ◽  
Ahmad Daryani ◽  
Ma de la Luz Galvan-Ramirez ◽  
Masoud Foroutan-Rad
Odontology ◽  
2011 ◽  
Vol 100 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Stefano Corbella ◽  
Silvio Taschieri ◽  
Luca Francetti ◽  
Francesca De Siena ◽  
Massimo Del Fabbro

2019 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  

Abstract Background Results of previous studies were showed that the association between H. pylori infection and the risk of diabetes is still controversies. Therefore, this systematic review and meta-analysis study was designed and implemented aimed to determine the association between H. pylori infection and the risk of diabetes.Methods All case control articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to March 2019 without language limitations. Also, logarithm and standard error logarithm odds ratio (OR) were used for meta-analysis.Results A total of 41 studies were included in this meta-analysis. The range of association with odds ratio in case control studies which published between 1990 to 2019 was 0.21 to 6.08. The pooled estimate of the association between H. pylori infection with diabetes was 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus, type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was higher than other population, but in the American, this was a protective relationship.Conclusion In conclusion, this systematic review & meta-analysis study suggested that H. pylori infection was associated with the risk of diabetes as compared to non- diabetes individual.


2012 ◽  
Vol 98 (3) ◽  
pp. 702-712.e6 ◽  
Author(s):  
Kelechi E. Nnoaham ◽  
Premila Webster ◽  
Jharna Kumbang ◽  
Stephen H. Kennedy ◽  
Krina T. Zondervan

2011 ◽  
Vol 140 (5) ◽  
pp. S-919
Author(s):  
Abdul S. Khan ◽  
Priyanka Tiwari ◽  
Jonathan P. Nass ◽  
Tuhama Rihani ◽  
Brian B. Borg ◽  
...  

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e040137
Author(s):  
Lihai Wang ◽  
Lei Zhong ◽  
Bin Xu ◽  
Min Chen ◽  
Hongxiao Huang

ObjectiveEmerging evidence from observational studies (cohort and case–control studies) suggests that a history of diabetes mellitus (DM) has been linked to increased risk of ovarian cancer (OC), but the association between them remains inconclusive. The aim of this systematic review and meta-analysis of observational studies was to clarify this association.DesignSystematic review and meta-analysis.MethodsWe searched PubMed, Embase and the Cochrane library databases published from the inception through 9 April 2020 without language restriction. Observational studies that evaluated the correlation between DM and the incidence of OC were included in our study. Relative risk (RR) with 95% CI was pooled by use of a random-effects model.ResultsA total of 36 epidemiological articles, including 9 case–control and 27 cohort studies, were finally enrolled, consisting of 14 496 incident cases of OC. Synthesised RRs of developing OC by history of DM were 1.20 (95% CI=1.10 to 1.31) for all eligible studies, 1.08 (95% CI=0.77 to 1.53) for case–control studies and 1.22 (95% CI=1.11 to 1.33) for cohort studies. The above-mentioned positive association persisted across most of subgroup analyses, whereas it was not significant among studies from North American and European countries, level of unadjusted, and patients with low-quality and gestational DM group. The cumulative meta-analysis and sensitivity analysis showed pooled effect was stable and reliable, and no apparent publication bias was identified in this study.ConclusionsOur study found weaker but still association between DM and OC risk. However, further well-designed prospective studies that control for potential confounders are warranted.


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