scholarly journals Ceramide generation as a novel biological mechanism for chemo-preventive and cytotoxic effects of hesperidin on HT-144 melanoma cells

2018 ◽  
Vol 7 (4) ◽  
pp. 640-645 ◽  
Author(s):  
Mahdi Mashhadi Akbar Boojar ◽  
Masoud Mashhadi Akbar Boojar ◽  
Sepide Golmohammad ◽  
Mojtaba Nikkhah Yazdi
Keyword(s):  
Melanoma Cells ◽  
Biological Mechanism ◽  
Cytotoxic Effects ◽  
Ceramide Generation

Photocatalytic and Cytotoxic Effects of Nitrogen-Doped TiO2 Nanoparticles on Melanoma Cells

2018 ◽  
Vol 18 (5) ◽  
pp. 3722-3728 ◽  
Author(s):  
Pedro Faria Zeni ◽  
Disley Prates Dos Santos ◽  
Rafael Renatino Canevarolo ◽  
José Andrés Yunes ◽  
Francine Ferreira Padilha ◽  
...  
Keyword(s):  
Tio2 Nanoparticles ◽  
Melanoma Cells ◽  
Cytotoxic Effects ◽  
Doped Tio2 ◽  
Nitrogen Doped

scholarly journals Fibroblasts Protect Melanoma Cells from the Cytotoxic Effects of Doxorubicin

2014 ◽  
Vol 20 (17-18) ◽  
pp. 2412-2421 ◽  
Author(s):  
Manoela Tiago ◽  
Edson Mendes de Oliveira ◽  
Carla Abdo Brohem ◽  
Paula Comune Pennacchi ◽  
Rafael Duarte Paes ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Cytotoxic Effects

Decitabine, independent of apoptosis, exerts its cytotoxic effects on cell growth in melanoma cells

2011 ◽  
Vol 32 (3) ◽  
pp. 423-429 ◽  
Author(s):  
Qian-Ying Liu ◽  
Da-Wei Chen ◽  
Li-Ping Xie ◽  
Rong-Qing Zhang ◽  
Hong-Zhong Wang
Keyword(s):  
Cell Growth ◽  
Melanoma Cells ◽  
Cytotoxic Effects

scholarly journals The Cytotoxic Effects of Betulin-Conjugated Gold Nanoparticles as Stable Formulations in Normal and Melanoma Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Marius Mioc ◽  
Ioana Zinuca Pavel ◽  
Roxana Ghiulai ◽  
Dorina E. Coricovac ◽  
Claudia Farcaş ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Melanoma Cells ◽  
Cytotoxic Effects

Cytotoxic effects of novel semisynthetic shikonin derivatives on melanoma cells

2017 ◽  
Author(s):  
C Durchschein ◽  
N Kretschmer ◽  
B Rinner ◽  
A Deutsch ◽  
A Stallinger ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Cytotoxic Effects ◽  
Shikonin Derivatives

Activation of Tyrosinase Reduces the Cytotoxic Effects of the Superoxide Anion in B16 Mouse Melanoma Cells

1996 ◽  
Vol 9 (2) ◽  
pp. 77-81 ◽  
Author(s):  
PALOMA VALVERDE ◽  
PHILIP MANNING ◽  
CALUM J. McNEIL ◽  
ANTHONY J. THODY
Keyword(s):  
Superoxide Anion ◽  
Melanoma Cells ◽  
Cytotoxic Effects ◽  
Mouse Melanoma ◽  
B16 Mouse Melanoma

scholarly journals Cytotoxicity of citral against melanoma cells: The involvement of oxidative stress generation and cell growth protein reduction

Tumor Biology ◽  
2017 ◽  
Vol 39 (3) ◽  
pp. 101042831769591 ◽  
Author(s):  
Larissa Juliani Sanches ◽  
Poliana Camila Marinello ◽  
Carolina Panis ◽  
Tatiane Renata Fagundes ◽  
José Andrés Morgado-Díaz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Nuclear Factor Kappa B ◽  
Melanoma Cells ◽  
Stress Generation ◽  
Nuclear Factor ◽  
Cytotoxic Effects

Citral is a natural compound that has shown cytotoxic and antiproliferative effects on breast and hematopoietic cancer cells; however, there are few studies on melanoma cells. Oxidative stress is known to be involved in all stages of melanoma development and is able to modulate intracellular pathways related to cellular proliferation and death. In this study, we hypothesize that citral exerts its cytotoxic effect on melanoma cells by the modulation of cellular oxidative status and/or intracellular signaling. To test this hypothesis, we investigated the antiproliferative and cytotoxic effects of citral on B16F10 murine melanoma cells evaluating its effects on cellular oxidative stress, DNA damage, cell death, and important signaling pathways, as these pathways, namely, extracellular signal-regulated kinases 1/2 (ERK1/2), AKT, and phosphatidylinositol-3 kinase, are involved in cell proliferation and differentiation. The p53 and nuclear factor kappa B were also investigated due to their ability to respond to intracellular stress. We observed that citral exerted antiproliferative and cytotoxic effects in B16F10; induced oxidative stress, DNA lesions, and p53 nuclear translocation; and reduced nitric oxide levels and nuclear factor kappa B, ERK1/2, and AKT. To investigate citral specificity, we used non-neoplastic human and murine cells, HaCaT (human skin keratinocytes) and NIH-3T3 cells (murine fibroblasts), and observed that although citral effects were not specific for cancer cells, non-neoplastic cells were more resistant to citral than B16F10. These findings highlight the potential clinical utility of citral in melanoma, with a mechanism of action involving the oxidative stress generation, nitric oxide depletion, and interference in signaling pathways related to cell proliferation.

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