scholarly journals The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target

2019 ◽  
Vol 122 (6) ◽  
pp. e157-e167 ◽  
Author(s):  
D.T. Chen ◽  
J.H. Pan ◽  
Y.H. Chen ◽  
W. Xing ◽  
Y. Yan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Marker ◽  
Opioid Receptor ◽  
Therapeutic Target ◽  
Poor Prognosis ◽  
Mu Opioid Receptor ◽  
Potential Therapeutic Target ◽  
Mu Opioid

scholarly journals TWIST1 is a molecular marker for a poor prognosis in oral cancer and represents a potential therapeutic target

Cancer ◽  
2013 ◽  
Vol 120 (3) ◽  
pp. 352-362 ◽  
Author(s):  
Sabrina Daniela da Silva ◽  
Moulay A. Alaoui-Jamali ◽  
Fernando Augusto Soares ◽  
Dirce Maria Carraro ◽  
Helena Paula Brentani ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Molecular Marker ◽  
Therapeutic Target ◽  
Poor Prognosis ◽  
Potential Therapeutic Target

scholarly journals Variation of the human mu-opioid receptor (OPRM1) gene predicts vulnerability to frustration

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alan M. Daniel ◽  
Brenda G. Rushing ◽  
Karla Y. Tapia Menchaca
Keyword(s):  
Individual Differences ◽  
Animal Models ◽  
Opioid Receptor ◽  
Receptor Gene ◽  
Emotional Reaction ◽  
Mu Opioid Receptor ◽  
Reward Processing ◽  
Physical Pain ◽  
Mu Opioid ◽  
Allelic Differences

AbstractUnderstanding the emotional reaction to loss, or frustration, is a critical problem for the field of mental health. Animal models of loss have pointed to the opioid system as a nexus of frustration, physical pain, and substance abuse. However, few attempts have been made to connect the results of animal models of loss to human behavior. Allelic differences in the human mu opioid receptor gene, notably the A118G single nucleotide polymorphism, have been linked to individual differences in pain sensitivity, depressive symptoms, and reward processing. The present study explored the relationship between A118G and behavior in two frustrating tasks in humans. Results showed that carriers of the mutant G-allele were slower to recover behavior following a reward downshift and abandoned a frustrating task earlier than those without the mutation. Additionally, G-carriers were more sensitive to physical pain. These results highlight the overlap between frustration and pain, and suggest that genetic variation in opioid tone may contribute to individual differences in vulnerability and resilience following emotional disturbances.

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