scholarly journals Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

2017 ◽  
Vol 91 ◽  
pp. 465-471 ◽  
Author(s):  
Da Chen ◽  
Shuren Song ◽  
Jilong Ma ◽  
Zhen Zhang ◽  
Peng Wang ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Whole Blood ◽  
Acoustic Sensor ◽  
Coagulation Monitoring ◽  
Film Bulk

Shear Mode Bulk Acoustic Viscosity Sensor for Blood Coagulation Monitoring in Oral Anticoagulant Therapy

2018 ◽  
Vol 18 (12) ◽  
pp. 8099-8104 ◽  
Author(s):  
Shuren Song ◽  
Da Chen ◽  
Hongfei Wang ◽  
Qiuquan Guo ◽  
Wangli Yu
Keyword(s):  
Blood Coagulation ◽  
Human Blood ◽  
Oral Anticoagulant ◽  
Acoustic Resonator ◽  
Shear Mode ◽  
Viscosity Change ◽  
Coagulation Monitoring ◽  
Wide Range ◽  
Film Bulk Acoustic Resonator ◽  
Film Bulk

Frequent monitoring of blood coagulation status is essential for patients receiving treatment with some oral anticoagulant agents. In this paper, we present a microelectromechanical film bulk acoustic resonator for the measurement of blood coagulation parameters. The resonator was made of an aluminum nitride piezoelectric film and operated in thickness shear resonance mode with a frequency of about 2 GHz. The resonant frequency showed a linear relationship with the viscosity of the environmental liquid over the wide range of 1–25 cP, falling within the physiological range of human blood. The coagulation process of human blood was monitored by following the frequency downshift due to the viscosity change. Therefore, the frequency response was used to determine quantitatively three clinically significant parameters being the enzymatic cascade time, the coagulation time and the clot degree. As a practical demonstration, the proposed micro-resonator was applied to monitor coagulation for one month in a patient taking the oral anticoagulant, warfarin, daily. The results measured by the resonator were consistent with those of the standard coagulometer. As a result of the excellent potential for integration, miniaturization and the availability of direct digital signals, the shear mode film bulk acoustic resonator has promising application for clinical and personal coagulation monitoring.

THE EFFECT OF EARLY BLOOD TRANSFUSION ON THE OUTCOME OF GASTROINTESTINAL HAEMORRHAGE

1987 ◽  
Author(s):  
S D Blair ◽  
S B Javanvrin ◽  
C N McCollum ◽  
R M Greenhalgh
Keyword(s):  
Blood Transfusion ◽  
Blood Coagulation ◽  
Whole Blood ◽  
Randomised Trial ◽  
Gastrointestinal Haemorrhage ◽  
Clotting Time ◽  
Prospective Randomised Trial ◽  
Coagulation Tests ◽  
To Receive ◽  
Upper Gastrointestinal

It has been suggested that mortality due to upper gastrointestinal haemorrhage may be reduced by restricting blood transfusion [1], We have assessed whether this is due to an anticoagulant effect in a prospective randomised trial.One hundred patients with severe, acute gastrointestinal haemorrhage were randomised to receive either at least 2 units of blood during the first 24 hours of admission, or no blood unless their haemaglobin was lessthan 8g/dl or they were shocked. Minor bleeds and varices were excluded As hypercoagulation cannot be measured using conventional coagulation tests, fresh whole blood coagulation was measured by the Biobridge Impedance Clotting Time (ICT). Coagulation was assessed at 24 hour intervals and compared to age matched controls with the results expressed as mean ± sem.The ICT on admission for the transfusion group (n=50) was 3.2±0.2 mins compared to 10±0.2 mins in controls. This hyper-coagulable state was partially reversed to 6.4±0.3 mins at 24 hours (p<0.001). The 50 allocated to receive no blood had a similar ICT on admission of 4.4±0.4 mins but the hypercoagulable state was maintained with ICT at 24 hours of 4.320.4 mins. Only 2 patients not transfused rebled compared to 15 in the early transfusion group (p<0.001). Five patients died, and they were all in the early transfusion group.These findings show there is a hypercoagulable response to haemorrhage which is partially reversed by blood transfusion leading to rebleeding

A Solid State Whole Blood Coagulation Time Device

1966 ◽  
Vol 46 (4) ◽  
pp. 463-471
Author(s):  
Joseph Beeman ◽  
Alma Miller ◽  
Sam CAmarena
Keyword(s):  
Solid State ◽  
Blood Coagulation ◽  
Whole Blood ◽  
Coagulation Time ◽  
Whole Blood Coagulation Time

Investigations of the Dose of Heparin and Whole Blood Coagulation Time during Endovascular Surgery

1997 ◽  
Vol 3 (2_suppl) ◽  
pp. 215-217 ◽  
Author(s):  
S. Nagai ◽  
A. Kurata ◽  
R. Tanaka ◽  
K. Irikura ◽  
Y. Miyasaka ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Whole Blood ◽  
Initial Level ◽  
Thrombus Formation ◽  
Constant Level ◽  
Bleeding Tendency ◽  
Coagulation Time ◽  
Continuous Administration ◽  
Heparin Administration ◽  
Whole Blood Coagulation Time

We chronologically determined whole blood coagulation time during continuous heparin administration, and investigated optimal doses of heparin in thirty-seven vascular surgery cases. ACT was determined with Hemochron 401. Heparin (2000 IU) was administered by bolus injection at the beginning of intravascular surgery, which was followed by continuous injection of 20 to 160 IU/kg/h. ACT determined before and 30 minutes after heparin administration were compared. There were no complications. ACT was maintained at a nearly constant level by continuous heparin administration. The dose of heparin required to maintain ACT at a level 1.5 to 2 times the initial level was 20 to 60 IU/kg/h. ACT was prolonged by more than three times in two of the ten subjects who were given heparin at a dose of 70 IU/kg/h or more. Continuous administration of heparin allowed maintenance of ACT at a nearly constant level during intravascular surgery. ACT was maintained within the range which is believed to be effective for prevention of thrombus formation (approximately 1.5 to 2.0 times larger than the initial level) by continuous administration of 20 to 60 IU/kg/h of heparin. ACT was, however, prolonged to more than three times the initial level in some subjects who were given 70 IU/kg/h or higher doses, suggesting the risk of a bleeding tendency. Accordingly, it is ideal to continue heparin administration at appropriate doses, while measuring ACT. The results of our study should serve as a useful standard for meeting this goal.

scholarly journals Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue

2009 ◽  
Vol 144 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Ole H. Larsen ◽  
Niels Clausen ◽  
Egon Persson ◽  
Mirella Ezban ◽  
Jørgen Ingerslev ◽  
...  
Keyword(s):  
Blood Coagulation ◽  
Whole Blood ◽  
Recombinant Factor Viia ◽  
Factor Viia ◽  
Potent Factor

scholarly journals Engineering a simple lateral flow device for animal blood coagulation monitoring

2018 ◽  
Vol 12 (1) ◽  
pp. 014110 ◽  
Author(s):  
Hua Li ◽  
Daewoo Han ◽  
Giovanni M. Pauletti ◽  
Andrew J. Steckl
Keyword(s):  
Blood Coagulation ◽  
Lateral Flow ◽  
Animal Blood ◽  
Lateral Flow Device ◽  
Coagulation Monitoring ◽  
Flow Device
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