Development of lipid A-imprinted polymer hydrogels that selectively recognize lipopolysaccharides

2012 ◽  
Vol 38 (1) ◽  
pp. 215-219 ◽  
Author(s):  
Kei-Ichi Ogawa ◽  
Masumi Hyuga ◽  
Tomoko Okada ◽  
Norihiko Minoura
Keyword(s):  
Lipid A ◽  
Imprinted Polymer ◽  
Polymer Hydrogels

Design of Temperature Sensitive Imprinted Polymer Hydrogels Based on Multiple-Point Hydrogen Bonding

2004 ◽  
Vol 4 (7) ◽  
pp. 680-684 ◽  
Author(s):  
Xue-Yong Liu ◽  
Ying Guan ◽  
Xiao-Bin Ding ◽  
Yu-Xing Peng ◽  
Xin-Ping Long ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Multiple Point ◽  
Temperature Sensitive ◽  
Imprinted Polymer ◽  
Polymer Hydrogels

Imprinted Polymer Hydrogels for the Separation of Viruses

2010 ◽  
Vol 291-292 (1) ◽  
pp. 302-306 ◽  
Author(s):  
Linden D. Bolisay ◽  
Peter Kofinas
Keyword(s):  
Imprinted Polymer ◽  
Polymer Hydrogels

Isomeric glucose recognition using molecularly imprinted polymer hydrogels

2003 ◽  
Vol 787 ◽  
Author(s):  
Paraskevi Parmpi ◽  
Linden D.V. Bolisay ◽  
Peter Kofinas
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Glucose Solution ◽  
Imprinted Polymer ◽  
Separation Techniques ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Polymer Hydrogels ◽  
Equilibrium Binding

ABSTRACTThe goal of this research is to produce molecular imprinted polymers (MIPs), which selectively bind glucose over other sugars. MIP hydrogels against glucose exhibited binding capacities in excess of 0.6 grams of glucose per gram of dry gel in a 100 % DI H2O glucose solution, as well as in a 50–50 % glucose-fructose solution mixture. Equilibrium binding capacities of fructose were lower than those observed with respect to glucose, indicating an isomeric preference for the binding of glucose over fructose. Although it is expected that imprinted cavities will be distorted due to the swelling of the hydrogel in water, our experiments show that even the swollen gels exhibit remarkable glucose recognition. This synthetic and characterization methodology for MIPs might thus offer exciting avenues for novel biomimetic recognition and isomeric separation techniques.

Separation of baculoviruses using molecularly imprinted polymer hydrogels

2003 ◽  
Vol 787 ◽  
Author(s):  
Linden D.V. Bolisay ◽  
John F. March ◽  
William E. Bentley ◽  
Peter Kofinas
Keyword(s):  
Animal Health ◽  
Crop Protection ◽  
Recombinant Baculovirus ◽  
Imprinted Polymer ◽  
Molecular Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Polymer Hydrogels ◽  
Aqueous Environments ◽  
Biological Analytes

ABSTRACTThe goal of this research is to develop molecular imprinted polymers (MIP) for biomimetic recognition of viruses. Our experimental results indicate that hydrogels can be produced, which can specifically and selectively bind recombinant baculoviruses. Although it is expected that imprinted cavities will be distorted due to the swelling of the hydrogel in water, our experiments show that even the swollen gels exhibit remarkable affinity toward recombinant baculovirus. The proposed methodologies for the synthesis and characterization of MIPs thus offer exciting avenues for the development of virus recognition techniques. The virus MIPs must function in aqueous environments. Our approach employs a more flexible non-covalent imprinting method, starting from a readily available polyamine polymer, and both MIP synthesis and testing are performed in aqueous solutions. The development of a virus imprinted MIP, which would apply to the identification, classification, and removal of viruses. This is currently a very difficult task, but the need is widespread in diverse sectors, including national security, human and animal health, crop protection, and biologics production. The development of general methods using MIPs capable of specific recognition of biological analytes would have an enormous value in medicine and bioanalytics.

Recognition ability of temperature responsive molecularly imprinted polymer hydrogels

Soft Matter ◽  
2011 ◽  
Vol 7 (5) ◽  
pp. 1986 ◽  
Author(s):  
Xueyong Liu ◽  
Tao Zhou ◽  
Ziwei Du ◽  
Zhong Wei ◽  
Junhua Zhang
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Polymer Hydrogels ◽  
Temperature Responsive ◽  
Recognition Ability

Design and fabrication of conductive polymer hydrogels and their applications in flexible supercapacitors

2020 ◽  
Vol 8 (44) ◽  
pp. 23059-23095 ◽  
Author(s):  
Xinting Han ◽  
Guangchun Xiao ◽  
Yuchen Wang ◽  
Xiaona Chen ◽  
Gaigai Duan ◽  
...  
Keyword(s):  
Conductive Polymer ◽  
Polymer Hydrogels ◽  
Conductive Materials ◽  
Flexible Supercapacitors

Conductive polymer hydrogels, which combine the advantages of both polymers and conductive materials, have huge potential in flexible supercapacitors.

Induction of Endothelial Tissue Factor by Endotoxin and Its Precursors

1993 ◽  
Vol 70 (04) ◽  
pp. 702-706 ◽  
Author(s):  
Charles F Moldow ◽  
Ronald R Bach ◽  
Katherine Staskus ◽  
Paul D Rick
Keyword(s):  
Tissue Factor ◽  
Lipid A ◽  
Umbilical Vein ◽  
Structural Determinants ◽  
Monophosphoryl Lipid A ◽  
Maximal Induction ◽  
Umbilical Vein Endothelial Cells ◽  
Acyloxyacyl Hydrolase ◽  
Endothelial Tissue ◽  
Specific Mrna

SummaryThe structural determinants of lipopolysaccharide required for the induction of tissue factor in human umbilical vein endothelial cells were studied. Intact lipid A was essential for the induction of tissue factor whereas the incomplete lipid A precursors lipid IVA and lipid X, as well as monophosphoryl lipid A and acyloxyacyl hydrolase-treated lipopolysaccharide, were unable to induce tissue factor and tissue factor specific mRNA. However, the lipid A precursor, lipid IVA, was able to inhibit LPS-mediated induction of tissue factor; structural determinants distal to lipid A were found to be required for maximal induction of tissue factor activity and tissue factor mRNA. The presence of serum in the assay was found to amplify but was not obligate for tissue factor induction by LPS.

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