AlGaN/GaN heterostructures for non-invasive cell electrophysiological measurements

2007 ◽  
Vol 23 (4) ◽  
pp. 513-519 ◽  
Author(s):  
Jinjiang Yu ◽  
Shrawan Kumar Jha ◽  
Lidan Xiao ◽  
Qingjun Liu ◽  
Ping Wang ◽  
...  
Keyword(s):  
Non Invasive ◽  
Electrophysiological Measurements ◽  
Invasive Cell

scholarly journals The electrical heart axis of the fetus between 18 and 24 weeks of gestation: A cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0256115
Author(s):  
Carlijn Lempersz ◽  
Lore Noben ◽  
Sally-Ann B. Clur ◽  
Edwin van den Heuvel ◽  
Zhouzhao Zhan ◽  
...  
Keyword(s):  
Reference Electrode ◽  
Frontal Plane ◽  
Fetal Anomaly ◽  
Detection Rates ◽  
Non Invasive ◽  
Combined Use ◽  
Electrophysiological Measurements ◽  
Fetal Electrocardiography ◽  
The Right ◽  
Electrocardiogram Ecg

Introduction A fetal anomaly scan in mid-pregnancy is performed, to check for the presence of congenital anomalies, including congenital heart disease (CHD). Unfortunately, 40% of CHD is still missed. The combined use of ultrasound and electrocardiography might boost detection rates. The electrical heart axis is one of the characteristics which can be deduced from an electrocardiogram (ECG). The aim of this study was to determine reference values for the electrical heart axis in healthy fetuses around 20 weeks of gestation. Material and methods Non-invasive fetal electrocardiography was performed subsequent to the fetal anomaly scan in pregnant women carrying a healthy singleton fetus between 18 and 24 weeks of gestation. Eight adhesive electrodes were applied on the maternal abdomen including one ground and one reference electrode, yielding six channels of bipolar electrophysiological measurements. After removal of interferences, a fetal vectorcardiogram was calculated and then corrected for fetal orientation. The orientation of the electrical heart axis was determined from this normalized fetal vectorcardiogram. Descriptive statistics were used on normalized cartesian coordinates to determine the average electrical heart axis in the frontal plane. Furthermore, 90% prediction intervals (PI) for abnormality were calculated. Results Of the 328 fetal ECGs performed, 281 were included in the analysis. The average electrical heart axis in the frontal plane was determined at 122.7° (90% PI: -25.6°; 270.9°). Discussion The average electrical heart axis of healthy fetuses around mid-gestation is oriented to the right, which is, due to the unique fetal circulation, in line with muscle distribution in the fetal heart.

Non-invasive cell-tracking methods for adoptive T cell therapies

2021 ◽  
Author(s):  
Jelter Van Hoeck ◽  
Christian Vanhove ◽  
Stefaan C. De Smedt ◽  
Koen Raemdonck
Keyword(s):  
T Cell ◽  
Cell Tracking ◽  
Cell Therapies ◽  
Non Invasive ◽  
Invasive Cell

scholarly journals Non-invasive Fetal Electrocardiography for Intrapartum Cardiotocography

2020 ◽  
Vol 8 ◽  
Author(s):  
Rik Vullings ◽  
Judith O. E. H. van Laar
Keyword(s):  
Heart Rate ◽  
Doppler Ultrasound ◽  
Fetal Heart Rate ◽  
Fetal Heart ◽  
Fetal Monitoring ◽  
Irreversible Damage ◽  
Scalp Electrode ◽  
Non Invasive ◽  
Electrophysiological Measurements ◽  
Fetal Electrocardiography

Fetal monitoring is important to diagnose complications that can occur during pregnancy. If detected timely, these complications might be resolved before they lead to irreversible damage. Current fetal monitoring mainly relies on cardiotocography, the simultaneous registration of fetal heart rate and uterine activity. Unfortunately, the technology to obtain the cardiotocogram has limitations. In current clinical practice the fetal heart rate is obtained via either an invasive scalp electrode, that poses risks and can only be applied during labor and after rupture of the fetal membranes, or via non-invasive Doppler ultrasound technology that is inaccurate and suffers from loss of signal, in particular in women with high body mass, during motion, or in preterm pregnancies. In this study, transabdominal electrophysiological measurements are exploited to provide fetal heart rate non-invasively and in a more reliable manner than Doppler ultrasound. The performance of the fetal heart rate detection is determined by comparing the fetal heart rate to that obtained with an invasive scalp electrode during intrapartum monitoring. The performance is gauged by comparing it to performances mentioned in literature on Doppler ultrasound and on two commercially-available devices that are also based on transabdominal fetal electrocardiography.

Non-invasive Cell-free Tumor DNA-based Detection of Breast Cancer-related Copy Number Variations

2014 ◽  
Vol 207 (6) ◽  
pp. 287-288
Author(s):  
Bernhard G. Zimmermann ◽  
Eser Kirkizlar ◽  
Matthew Hill ◽  
Tudor Constantin ◽  
Styrmir Sigurjonsson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Copy Number Variations ◽  
Non Invasive ◽  
Invasive Cell ◽  
Tumor Dna

The non-invasive cell surface modification of hepatocytes with PEG-lipid derivatives

Biomaterials ◽  
2012 ◽  
Vol 33 (3) ◽  
pp. 821-828 ◽  
Author(s):  
Kohei Tatsumi ◽  
Kazuo Ohashi ◽  
Yuji Teramura ◽  
Rie Utoh ◽  
Kazuko Kanegae ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Surface ◽  
Non Invasive ◽  
Invasive Cell

scholarly journals Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Meike Paschen ◽  
Tilo Moede ◽  
Barbara Leibiger ◽  
Stefan Jacob ◽  
Galyna Bryzgalova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Type ◽  
In Vivo Monitoring ◽  
Non Invasive ◽  
Invasive Cell

scholarly journals Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential

2021 ◽  
Author(s):  
Martina Paumann-Page ◽  
Nikolaus Ferdinand Kienzl ◽  
Jyoti Motwani ◽  
Boushra Boushra Bathish ◽  
Louise N Paton ◽  
...  
Keyword(s):  
Metastatic Melanoma ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Collagen Iv ◽  
Metastatic Melanoma Cell ◽  
Protein Levels ◽  
Non Invasive ◽  
Hypobromous Acid ◽  
Invasive Cell ◽  
Melanoma Cell Lines

Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxidasin acts in cancer cells. We have analyzed peroxidasin protein expression and activity in eight metastatic melanoma cell lines using an ELISA developed with an in-house peroxidasin binding protein. RNAseq data analysis confirmed high peroxidasin mRNA expression in the five cell lines classified as invasive and low expression in the three non-invasive cell lines. Protein levels of peroxidasin were higher in the cell lines with an invasive phenotype. Active peroxidasin was secreted to the cell culture medium, where it accumulated over time, and peroxidasin protein levels in the medium were also much higher in invasive than non-invasive cell lines. The only well-established physiological role of peroxidasin is in the formation of a sulfilimine bond, which cross-links collagen IV in basement membranes via catalyzed oxidation of bromide to hypobromous acid. We found that peroxidasin secreted from melanoma cells formed sulfilimine bonds in uncross-linked collagen IV, confirming peroxidasin activity and hypobromous acid formation. Moreover, 3-bromotyrosine, a stable product of hypobromous acid reacting with tyrosine residues, was detected in invasive melanoma cells, substantiating that their expression of peroxidasin generates hypobromous acid, and showing that it does not exclusively react with collagen IV, but also with other biomolecules.

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