Quartz crystal microbalance-with dissipation monitoring (QCM-D) for real time measurements of blood coagulation density and immune complement activation on artificial surfaces

2005 ◽  
Vol 21 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Marcus Andersson ◽  
Jonas Andersson ◽  
Anders Sellborn ◽  
Mattias Berglin ◽  
Bo Nilsson ◽  
...  
Keyword(s):  
Real Time ◽  
Blood Coagulation ◽  
Quartz Crystal Microbalance ◽  
Complement Activation ◽  
Quartz Crystal ◽  
Artificial Surfaces

scholarly journals A Real-Time Method for Improving Stability of Monolithic Quartz Crystal Microbalance Operating under Harsh Environmental Conditions

Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4166
Author(s):  
Román Fernández ◽  
María Calero ◽  
Yolanda Jiménez ◽  
Antonio Arnau
Keyword(s):  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Limit Of Detection ◽  
Quartz Substrate ◽  
Low Cost ◽  
Discrete Wavelet ◽  
Reagent Consumption ◽  
Measurement Cell ◽  
The Stability

Monolithic quartz crystal microbalance (MQCM) has recently emerged as a very promising technology suitable for biosensing applications. These devices consist of an array of miniaturized QCM sensors integrated within the same quartz substrate capable of detecting multiple target analytes simultaneously. Their relevant benefits include high throughput, low cost per sensor unit, low sample/reagent consumption and fast sensing response. Despite the great potential of MQCM, unwanted environmental factors (e.g., temperature, humidity, vibrations, or pressure) and perturbations intrinsic to the sensor setup (e.g., mechanical stress exerted by the measurement cell or electronic noise of the characterization system) can affect sensor stability, masking the signal of interest and degrading the limit of detection (LoD). Here, we present a method based on the discrete wavelet transform (DWT) to improve the stability of the resonance frequency and dissipation signals in real time. The method takes advantage of the similarity among the noise patterns of the resonators integrated in an MQCM device to mitigate disturbing factors that impact on sensor response. Performance of the method is validated by studying the adsorption of proteins (neutravidin and biotinylated albumin) under external controlled factors (temperature and pressure/flow rate) that simulate unwanted disturbances.

scholarly journals Probing the interaction of nanoparticles with small molecules in real time via quartz crystal microbalance monitoring

Nanoscale ◽  
2019 ◽  
Vol 11 (23) ◽  
pp. 11107-11113 ◽  
Author(s):  
Ye Yang ◽  
Guillaume Poss ◽  
Yini Weng ◽  
Runzhang Qi ◽  
Hanrui Zheng ◽  
...  
Keyword(s):  
Small Molecules ◽  
Real Time ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Binding Affinities ◽  
Target Analytes

We report on a novel screening route to obtain quantitative measures for nanoparticle binding affinities to target analytes.

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