scholarly journals An investigation into the butyrylcholinesterase-catalyzed hydrolysis of formylthiocholine using heavy atom kinetic isotope effects

2016 ◽  
Vol 65 ◽  
pp. 57-60 ◽  
Author(s):  
Emily J. Fogle ◽  
John F. Marlier ◽  
Anthony Stillman ◽  
Xin Gao ◽  
Yashas Rao ◽  
...  
Keyword(s):  
Isotope Effects ◽  
Heavy Atom ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope ◽  
Hydrolysis Of

Theoretical Simulations of Heavy-Atom Kinetic Isotope Effects in Aliphatic Claisen Rearrangement

2020 ◽  
Vol 124 (51) ◽  
pp. 10678-10686
Author(s):  
Yuqing Xu ◽  
Kin-Yiu Wong ◽  
Meishan Wang ◽  
Desheng Liu ◽  
Wenkai Zhao ◽  
...  
Keyword(s):  
Claisen Rearrangement ◽  
Isotope Effects ◽  
Heavy Atom ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope ◽  
Theoretical Simulations

Vinyl ether hydrolysis. XIII. The failure of I-strain to produce a change in rate-determining step

1980 ◽  
Vol 58 (2) ◽  
pp. 124-129 ◽  
Author(s):  
Y. Chiang ◽  
W. K. Chwang ◽  
A. J. Kresge ◽  
S. Szilagyi
Keyword(s):  
Vinyl Ether ◽  
Acid Catalysis ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Mineral Acid ◽  
Buffer Solutions ◽  
Rate Determining Step ◽  
Kinetic Isotope ◽  
Acetic Acid Buffer ◽  
Hydrolysis Of

Rates of hydrolysis of 1-ethoxy-3,3,5,5-tetramethylcyclopentene and 1-methoxy-2,3,3,5,5-pentamethylcyclopentene measured in mineral acid and formic and acetic acid buffer solutions show general acid catalysis and give large kinetic isotope effects in the normal direction (kH/kD > 1). This indicates that these reactions proceed by the conventional mechanism for vinyl ether hydrolysis in which proton transfer from the catalyzing acid to the substrate is rate-determining, and that the I-strain in these substrates is insufficiently great to shift the reaction mechanism to rapidly reversible substrate protonation followed by rate-determining hydration of the ensuing cationic intermediate.

ALPHA-SECONDARY DEUTERIUM KINETIC ISOTOPE EFFECTS FOR HYDROLYSIS OF TREHALOSE BY TREHALASE

2002 ◽  
Author(s):  
Jin-Ha Lee ◽  
Mamoru Nishimoto ◽  
Masayuki Okuyama ◽  
Haruhide Mori ◽  
Atsuo Kimura ◽  
...  
Keyword(s):  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope ◽  
Hydrolysis Of
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