H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats

Biochimie ◽  
2016 ◽  
Vol 131 ◽  
pp. 68-76 ◽  
Author(s):  
Anuradha Pandey ◽  
Santosh Kumar Goru ◽  
Almesh Kadakol ◽  
Vajir Malek ◽  
Nisha Sharma ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Renal Fibrosis ◽  
Diabetic Rats ◽  
Macrophage Infiltration ◽  
Angiotensin Ii Receptor ◽  
Type 2 Diabetic

scholarly journals The angiotensin II receptor-neprilysin inhibitor LCZ696 attenuates the progression of proteinuria in type 2 diabetic rats

2020 ◽  
Vol 142 (3) ◽  
pp. 124-126 ◽  
Author(s):  
Asadur Rahman ◽  
Shamshad J. Sherajee ◽  
Kazi Rafiq ◽  
Hideki Kobara ◽  
Tsutomu Masaki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Angiotensin Ii Receptor ◽  
Neprilysin Inhibitor ◽  
Type 2 Diabetic

scholarly journals A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats

2008 ◽  
Vol 28 (10) ◽  
pp. 1767-1773 ◽  
Author(s):  
Yuko Izuhara ◽  
Toshio Sada ◽  
Hiroaki Yanagisawa ◽  
Hiroyuki Koike ◽  
Shuichi Ohtomo ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Receptor Affinity ◽  
Type 2 Diabetic

Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats

2011 ◽  
Vol 300 (4) ◽  
pp. E708-E716 ◽  
Author(s):  
Qiao-Yan Guo ◽  
Li-Ning Miao ◽  
Bing Li ◽  
Fu-Zhe Ma ◽  
Nian Liu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Diabetic Rats ◽  
Ang Ii ◽  
Direct Infusion ◽  
Protein Expressions ◽  
12 Lipoxygenase ◽  
Type 2 Diabetic

12-lipoxygenase (12-LO) was implicated in the development of diabetic nephropathy (DN), in which the proteinuria was thought to be associated with a decreased expression of glomerular P-cadherin. Therefore, we investigated the role of 12-LO in the glomerular P-cadherin expression in type 2 diabetic rats according to the glomerular sizes. Rats fed with high-fat diet for 6 wk were treated with low-dose streptozotocin. Once diabetes onset, diabetic rats were treated with 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) for 8 wk. Then glomeruli were isolated from diabetic and control rats with a sieving method. RT-PCR, Western blotting, and immunofluorescent staining were used for mRNA and protein expressions of P-cadherin and angiotensin II (Ang II) type 1 receptor (AT1). We found that CDC did not affect the glucose levels but completely attenuated diabetic increases in glomerular volume and proteinuria. Diabetes significantly decreased the P-cadherin mRNA and protein expressions and increased the AT1 mRNA and protein expressions in the glomeruli. These changes were significantly prevented by CDC and recaptured by direct infusion of 12-LO product [12(S)-HETE] to normal rats for 7 days. The decreased P-cadherin expression was similar between large and small glomeruli, but the increased AT1 expression was significantly higher in the large than in the small glomeruli from diabetic and 12(S)-HETE-treated rats. Direct infusion of normal rats with Ang II for 14 days also significantly decreased the glomerular P-cadherin expression. These results suggest that diabetic proteinuria is mediated by the activation of 12-LO pathway that is partially attributed to the decreased glomerular P-cadherin expression.

An angiotensin II receptor blocker increases sexual behavior in type 2 diabetic mice

2007 ◽  
Vol 91 (2-3) ◽  
pp. 223-228 ◽  
Author(s):  
Masayoshi Nomura ◽  
Hisae Nishii ◽  
Yumi Ozaki ◽  
Naohiro Fujimoto ◽  
Tetsuro Matsumoto
Keyword(s):  
Sexual Behavior ◽  
Angiotensin Ii ◽  
Receptor Blocker ◽  
Angiotensin Ii Receptor Blocker ◽  
Diabetic Mice ◽  
Angiotensin Ii Receptor ◽  
Type 2 Diabetic
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