Key enzymes for biosynthesis of neutral lipid storage compounds in prokaryotes: Properties, function and occurrence of wax ester synthases/acyl-CoA:diacylglycerol acyltransferases

Biochimie ◽  
2007 ◽  
Vol 89 (2) ◽  
pp. 230-242 ◽  
Author(s):  
Marc Wältermann ◽  
Tim Stöveken ◽  
Alexander Steinbüchel
Keyword(s):  
Neutral Lipid ◽  
Lipid Storage ◽  
Wax Ester ◽  
Key Enzymes ◽  
Storage Compounds

Lipid storage compounds in raw activated sludge microorganisms for biofuels and oleochemicals production

RSC Advances ◽  
2012 ◽  
Vol 2 (5) ◽  
pp. 2015 ◽  
Author(s):  
Emmanuel D. Revellame ◽  
Rafael Hernandez ◽  
William French ◽  
William E. Holmes ◽  
Tracy J. Benson ◽  
...  
Keyword(s):  
Activated Sludge ◽  
Lipid Storage ◽  
Storage Compounds

68. Linoleic acid increases neutral lipid storage during bovine oocyte maturation

Cryobiology ◽  
2012 ◽  
Vol 65 (3) ◽  
pp. 361
Author(s):  
María de las Mercedes Carro ◽  
Glenda Rios ◽  
Gerardo Martín Oresti ◽  
Jorgelina Buschiazzo ◽  
Ricardo Alberio
Keyword(s):  
Linoleic Acid ◽  
Neutral Lipid ◽  
Oocyte Maturation ◽  
Lipid Storage ◽  
Bovine Oocyte

Neutral lipid storage disease with myopathy: Further phenotypic characterization of a rare PNPLA2 variant

2018 ◽  
Vol 28 (7) ◽  
pp. 606-609 ◽  
Author(s):  
Caitlin S. Latimer ◽  
Jennifer Schleit ◽  
Adam Reynolds ◽  
Desiree A. Marshall ◽  
Benjamin Podemski ◽  
...  
Keyword(s):  
Neutral Lipid ◽  
Storage Disease ◽  
Lipid Storage ◽  
Phenotypic Characterization ◽  
Lipid Storage Disease ◽  
Neutral Lipid Storage Disease

scholarly journals Genome-Wide Analysis of Sterol-Lipid Storage and Trafficking in Saccharomyces cerevisiae

2007 ◽  
Vol 7 (2) ◽  
pp. 401-414 ◽  
Author(s):  
Weihua Fei ◽  
Gabriel Alfaro ◽  
Baby-Periyanayaki Muthusamy ◽  
Zachary Klaassen ◽  
Todd R. Graham ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Neutral Lipid ◽  
Lipid Synthesis ◽  
Secretory Protein ◽  
Lipid Storage ◽  
Protein Glycosylation ◽  
Particle Assembly ◽  
Genome Wide ◽  
And Storage

ABSTRACT The pandemic of lipid-related disease necessitates a determination of how cholesterol and other lipids are transported and stored within cells. The first step in this determination is the identification of the genes involved in these transport and storage processes. Using genome-wide screens, we identified 56 yeast (Saccharomyces cerevisiae) genes involved in sterol-lipid biosynthesis, intracellular trafficking, and/or neutral-lipid storage. Direct biochemical and cytological examination of mutant cells revealed an unanticipated link between secretory protein glycosylation and triacylglycerol (TAG)/steryl ester (SE) synthesis for the storage of lipids. Together with the analysis of other deletion mutants, these results suggested at least two distinct events for the biogenesis of lipid storage particles: a step affecting neutral-lipid synthesis, generating the lipid core of storage particles, and another step for particle assembly. In addition to the lipid storage mutants, we identified mutations that affect the localization of unesterified sterols, which are normally concentrated in the plasma membrane. These findings implicated phospholipase C and the protein phosphatase Ptc1p in the regulation of sterol distribution within cells. This study identified novel sterol-related genes that define several distinct processes maintaining sterol homeostasis.

scholarly journals Neutral Lipid Storage Disease Associated with the PNPLA2 Gene: Case Report and Literature Review

2020 ◽  
Vol 83 (3) ◽  
pp. 317-322
Author(s):  
Makoto Samukawa ◽  
Naoko Nakamura ◽  
Makito Hirano ◽  
Miyuki Morikawa ◽  
Hanami Sakata ◽  
...  
Keyword(s):  
Neutral Lipid ◽  
Storage Disease ◽  
Clinical Laboratory ◽  
Lipid Storage ◽  
Compound Heterozygous ◽  
Homozygous Mutation ◽  
Lipid Storage Disease ◽  
Consistent Finding ◽  
Pulmonary Cysts ◽  
Neutral Lipid Storage Disease

Mutations in the PNPLA2 gene cause neutral lipid storage disease with myopathy (NLSDM) or triglyceride deposit cardiomyovasculopathy. We report a detailed case study of a 53-year-old man with NLSDM. The PNPLA2 gene was analyzed according to the reported method. We summarized the clinical, laboratory, and genetic information of 56 patients, including our patient and 55 other reported patients with homozygous or compound heterozygous mutations in the PNPLA2 gene. We found a novel homozygous mutation (c.194delC) in the PNPLA2 gene that resulted in frameshift. The patient suffered from normal-tension glaucoma and pulmonary cysts, symptoms that are relatively common in the elderly but were not previously reported for this disease. Our summary confirmed that Jordan’s anomaly, polymorphonuclear leukocytes with lipid accumulation, was the most consistent finding of this disease. Because this disease is potentially treatable, our results may help rapid and correct diagnosis.

Neutral lipid storage disease co-existing with ichthyosiform dermatosis

1994 ◽  
Vol 153 (3) ◽  
pp. 210-211 ◽  
Author(s):  
A. Dursun ◽  
A. Kubar ◽  
A. Gokoz ◽  
F. Duru ◽  
A. Gürgey
Keyword(s):  
Neutral Lipid ◽  
Storage Disease ◽  
Lipid Storage ◽  
Lipid Storage Disease ◽  
Neutral Lipid Storage Disease

Neutral lipid-storage disease with myopathy and extended phenotype with novelPNPLA2mutation

2016 ◽  
Vol 53 (4) ◽  
pp. 644-648 ◽  
Author(s):  
Roberto Massa ◽  
Simone Pozzessere ◽  
Emanuele Rastelli ◽  
Laura Serra ◽  
Chiara Terracciano ◽  
...  
Keyword(s):  
Neutral Lipid ◽  
Storage Disease ◽  
Lipid Storage ◽  
Extended Phenotype ◽  
Lipid Storage Disease ◽  
Neutral Lipid Storage Disease
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