PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

PREGNANCY PROTEINS IN THE HUMAN - BIOLOGICAL AND CLINICAL SIGNIFICANCE

Pregnancy Proteins in Animals ◽

10.1515/9783110858167-003 ◽

1986 ◽

pp. 9-20

Author(s):

T. Chard

Keyword(s):

Clinical Significance ◽

Pregnancy Proteins

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PREGNANCY PROTEINS AND THE ACUTE-PHASE RESPONSE

Pregnancy Proteins in Animals ◽

10.1515/9783110858167-021 ◽

1986 ◽

pp. 195-212 ◽

Cited By ~ 2

Author(s):

Gillian T. Waites ◽

S. C. Bell

Keyword(s):

Acute Phase ◽

Acute Phase Response ◽

Phase Response ◽

Pregnancy Proteins

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PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS

The Lancet ◽

10.1016/s0140-6736(76)90731-5 ◽

1976 ◽

Vol 308 (7980) ◽

pp. 279-282 ◽

Cited By ~ 84

Author(s):

C.H.W Horne ◽

I.N Reid ◽

G.D Milne

Keyword(s):

Prognostic Significance ◽

Breast Cancers ◽

Pregnancy Proteins

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PROGNOSTIC SIGNIFICANCE OF SPECIFIC PROTEINS OF PREGNANCY IN WOMEN WITH A UTERINE AT SCAR AND PLACENTA ACCRETA

Russian Clinical Laboratory Diagnostics ◽

10.18821/0869-2084-2020-65-6-353-357 ◽

2020 ◽

Vol 65 (6) ◽

pp. 353-357

Author(s):

Vladimir Anatolyevich Borovkov ◽

M. B. Igitova ◽

Y. V. Korenovskiy ◽

Yu. A. Dudareva

Keyword(s):

Pregnant Women ◽

Placenta Accreta ◽

Screening Program ◽

Protein A ◽

Prognostic Significance ◽

Pregnancy Proteins ◽

Diagnostic Thresholds ◽

Diagnostic Threshold ◽

Specific Proteins

Comparative analysis of serum concentrations of chorionic gonadotropin (hCG) associated with the pregnancy of plasma protein A (PAPP-A) and alpha-fetoprotein (AFP), based on the results of a survey of women as part of a standard screening program (the results were expressed as a MoM - multiply of the median), found a significant increase in the performance of all the studied specific pregnancy proteins in women with a scar on the uterus and placenta acctera (75 patients) compared with the data of the group of pregnant women without scar on the uterus and without abnormalities of attachment of the placenta (150 women). AFP indices were 1.68 ± 0.76 and 1.19 ± 0.43 MoM (p = 0.0018), hCG - 1.62 ± 1.48 and 1.23 ± 0.76 MoM (p = 0, 0112), PAPP-A - 1.93 ± 1.24 and 1.23 ± 0.67 MoM (p <0.0001). Using the ROC analysis, the diagnostic thresholds for the concentrations of AFP, hCG and PAPP-A were calculated. The risk of placenta accreta in women with a scar on the uterus in cases of exceeding the diagnostic threshold of AFP concentration (1.64 MoM) increased 2.5 times (RR = 2.5; 95% CI 1.17-5.36, p = 0, 0185), hCG (1.41 MoM) - 1.6 times (RR = 1.59; 95% CI 1.09-2.32, p = 0.0147), PAPP-A (1.41 MoM) - 2.65 times (RR = 2.65; 95% CI 1.76-3.99, p <0.0001). Determination of the level of specific pregnancy proteins can be used in the system of complex prediction of placental growth in pregnant women with a scar on the uterus as an addition to the assessment of clinical and anamnestic risk factors.

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