scholarly journals RecQL4 cytoplasmic localization: Implications in mitochondrial DNA oxidative damage repair

2012 ◽  
Vol 44 (11) ◽  
pp. 1942-1951 ◽  
Author(s):  
Zhenfen Chi ◽  
Linghu Nie ◽  
Zhao Peng ◽  
Qiong Yang ◽  
Kuan Yang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Cytoplasmic Localization ◽  
Dna Oxidative Damage ◽  
Damage Repair

scholarly journals The Relationship between Nkx2.1 and DNA Oxidative Damage Repair in Nickel Smelting Workers: Jinchang Cohort Study

2019 ◽  
Vol 16 (1) ◽  
pp. 120 ◽  
Author(s):  
Zhiyuan Cheng ◽  
Ning Cheng ◽  
Dian Shi ◽  
Xiaoyu Ren ◽  
Ting Gan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Repair ◽  
Oxidative Damage ◽  
Underlying Mechanism ◽  
Dna Oxidative Damage ◽  
Damage Repair ◽  
Smad2 Phosphorylation ◽  
Nickel Exposure ◽  
Nickel Smelting ◽  
The Relationship

Background: Occupational nickel exposure can cause DNA oxidative damage and influence DNA repair. However, the underlying mechanism of nickel-induced high-risk of lung cancer has not been fully understood. Our study aims to evaluate whether the nickel-induced oxidative damage and DNA repair were correlated with the alterations in Smad2 phosphorylation status and Nkx2.1 expression levels, which has been considered as the lung cancer initiation gene. Methods: 140 nickel smelters and 140 age-matched administrative officers were randomly stratified by service length from Jinchang Cohort. Canonical regression, χ2 test, Spearman correlation etc. were used to evaluate the association among service length, MDA, 8-OHdG, hOGG1, PARP, pSmad2, and Nkx2.1. Results: The concentrations of MDA, PARP, pSmad2, and Nkx2.1 significantly increased. Nkx2.1 (rs = 0.312, p < 0.001) and Smad2 phosphorylation levels (rs = 0.232, p = 0.006) were positively correlated with the employment length in nickel smelters, which was not observed in the administrative officer group. Also, elevation of Nkx2.1 expression was positively correlated with service length, 8-OHdG, PARP, hOGG1 and pSmad2 levels in nickel smelters. Conclusions: Occupational nickel exposure could increase the expression of Nkx2.1 and pSmad2, which correlated with the nickel-induced oxidative damage and DNA repair change.

Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro

2005 ◽  
Vol 39 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Liu-Ji Chen ◽  
Yan-Qin Gao ◽  
Xue-Jun Li ◽  
Di-Han Shen ◽  
Feng-Yan Sun
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Dna Oxidative Damage

scholarly journals D-galactose-induced mitochondrial DNA oxidative damage in the auditory cortex of rats

2014 ◽  
Vol 10 (6) ◽  
pp. 2861-2867 ◽  
Author(s):  
ZHENGDE DU ◽  
QIONG YANG ◽  
TAO ZHOU ◽  
LIN LIU ◽  
SHUO LI ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Auditory Cortex ◽  
Dna Oxidative Damage

scholarly journals Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

2013 ◽  
Vol 18 (18) ◽  
pp. 2444-2457 ◽  
Author(s):  
Renato X. Santos ◽  
Sónia C. Correia ◽  
Xiongwei Zhu ◽  
Mark A. Smith ◽  
Paula I. Moreira ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Dna Oxidative Damage

Increased mitochondrial DNA oxidative damage after transient middle cerebral artery occlusion in mice

2007 ◽  
Vol 58 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Hirokazu Ohtaki ◽  
Takaaki Takeda ◽  
Kenji Dohi ◽  
Sachiko Yofu ◽  
Tomoya Nakamachi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Oxidative Damage ◽  
Middle Cerebral Artery ◽  
Middle Cerebral Artery Occlusion ◽  
Cerebral Artery ◽  
Artery Occlusion ◽  
Dna Oxidative Damage ◽  
Cerebral Artery Occlusion
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