Mechanism of folate deficiency-induced apoptosis in mouse embryonic stem cells: Cell cycle arrest/apoptosis in G1/G0 mediated by microRNA-302a and tumor suppressor gene Lats2

2012 ◽  
Vol 44 (11) ◽  
pp. 1750-1760 ◽  
Author(s):  
Yan Liang ◽  
Yuanyuan Li ◽  
Zhengli Li ◽  
Zhuo Liu ◽  
Zhiping Zhang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Tumor Suppressor Gene ◽  
Embryonic Stem ◽  
Suppressor Gene ◽  
Cycle Arrest ◽  
Induced Apoptosis

scholarly journals Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest

Stem Cells ◽  
2020 ◽  
Vol 38 (5) ◽  
pp. 613-623
Author(s):  
Suveg Pandey ◽  
Kelly M. Banks ◽  
Ritu Kumar ◽  
Andrew Kuo ◽  
Duancheng Wen ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Cycle Arrest ◽  
Sphingosine Kinases

scholarly journals DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells

2015 ◽  
Vol 149 (3) ◽  
pp. 693-703 ◽  
Author(s):  
Marleen Ansems ◽  
Jonas Nørskov Søndergaard ◽  
Anieta M. Sieuwerts ◽  
Maaike W. G. Looman ◽  
Marcel Smid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Breast Cancer Cells ◽  
Suppressor Gene ◽  
Cycle Arrest ◽  
Positive Breast Cancer

p53-independent DNA repair and cell cycle arrest in embryonic stem cells

FEBS Letters ◽  
1998 ◽  
Vol 425 (3) ◽  
pp. 499-504 ◽  
Author(s):  
Sandrine Prost ◽  
Christopher O.C Bellamy ◽  
Alan R Clarke ◽  
Andrew H Wyllie ◽  
David J Harrison
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Dna Repair ◽  
Embryonic Stem Cells ◽  
Cell Cycle Arrest ◽  
Embryonic Stem ◽  
Cycle Arrest

scholarly journals BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer

2009 ◽  
Vol 30 (4) ◽  
pp. 662-670 ◽  
Author(s):  
S. Majid ◽  
A. A. Dar ◽  
A. E. Ahmad ◽  
H. Hirata ◽  
K. Kawakami ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Histone Modification ◽  
Cell Cycle Arrest ◽  
Tumor Suppressor Gene ◽  
Renal Cancer ◽  
Gene Promoter ◽  
Suppressor Gene ◽  
Cycle Arrest

scholarly journals Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 ◽  
Vol 22 (18) ◽  
pp. 6521-6532 ◽  
Author(s):  
Atsushi Hirao ◽  
Alison Cheung ◽  
Gordon Duncan ◽  
Pierre-Marie Girard ◽  
Andrew J. Elia ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Ataxia Telangiectasia ◽  
Hair Follicles ◽  
Ataxia Telangiectasia Mutated ◽  
Independent Manner ◽  
Li Fraumeni Syndrome ◽  
Cycle Arrest ◽  
Induced Apoptosis

ABSTRACT In response to ionizing radiation (IR), the tumor suppressor p53 is stabilized and promotes either cell cycle arrest or apoptosis. Chk2 activated by IR contributes to this stabilization, possibly by direct phosphorylation. Like p53, Chk2 is mutated in patients with Li-Fraumeni syndrome. Since the ataxia telangiectasia mutated (ATM) gene is required for IR-induced activation of Chk2, it has been assumed that ATM and Chk2 act in a linear pathway leading to p53 activation. To clarify the role of Chk2 in tumorigenesis, we generated gene-targeted Chk2-deficient mice. Unlike ATM−/− and p53−/− mice, Chk2−/− mice do not spontaneously develop tumors, although Chk2 does suppress 7,12-dimethylbenzanthracene-induced skin tumors. Tissues from Chk2−/− mice, including those from the thymus, central nervous system, fibroblasts, epidermis, and hair follicles, show significant defects in IR-induced apoptosis or impaired G1/S arrest. Quantitative comparison of the G1/S checkpoint, apoptosis, and expression of p53 proteins in Chk2−/− versus ATM−/− thymocytes suggested that Chk2 can regulate p53-dependent apoptosis in an ATM-independent manner. IR-induced apoptosis was restored in Chk2−/− thymocytes by reintroduction of the wild-type Chk2 gene but not by a Chk2 gene in which the sites phosphorylated by ATM and ataxia telangiectasia and rad3 + related (ATR) were mutated to alanine. ATR may thus selectively contribute to p53-mediated apoptosis. These data indicate that distinct pathways regulate the activation of p53 leading to cell cycle arrest or apoptosis.

scholarly journals 3p21.3 Tumor Suppressor Gene H37/Luca15/RBM5 Inhibits Growth of Human Lung Cancer Cells through Cell Cycle Arrest and Apoptosis

2006 ◽  
Vol 66 (7) ◽  
pp. 3419-3427 ◽  
Author(s):  
Juliana J. Oh ◽  
Ali Razfar ◽  
Idolina Delgado ◽  
Rebecca A. Reed ◽  
Anna Malkina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Tumor Suppressor ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Human Lung ◽  
Suppressor Gene ◽  
Human Lung Cancer ◽  
Cycle Arrest ◽  
Human Lung Cancer Cells
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