Insulin-like growth factors control cell migration in health and disease

2007 ◽  
Vol 39 (5) ◽  
pp. 890-909 ◽  
Author(s):  
Marina A. Guvakova
Keyword(s):  
Cell Migration ◽  
Growth Factors ◽  
Control Cell ◽  
Health And Disease ◽  
Insulin Like Growth Factors

Insulin-like growth factors in vitreous. Studies in control and diabetic subjects with neovascularization

Diabetes ◽  
1986 ◽  
Vol 35 (4) ◽  
pp. 416-420 ◽  
Author(s):  
M. Grant ◽  
B. Russell ◽  
C. Fitzgerald ◽  
T. J. Merimee
Keyword(s):  
Growth Factors ◽  
Insulin Like Growth Factors

Von Willebrand factor (VIII R:Ag), fibronectin, and insulin-like growth factors I and II in diabetic retinopathy and nephropathy

Diabetes ◽  
1984 ◽  
Vol 33 (2) ◽  
pp. 125-129 ◽  
Author(s):  
R. P. Lamberton ◽  
A. D. Goodman ◽  
A. Kassoff ◽  
C. L. Rubin ◽  
D. H. Treble ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Growth Factors ◽  
Factor Viii ◽  
Von Willebrand Factor ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Insulin Like Growth Factors

scholarly journals Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling

2019 ◽  
Vol 30 (12) ◽  
pp. 1437-1450 ◽  
Author(s):  
Divyesh Joshi ◽  
Maneesha S. Inamdar
Keyword(s):  
Cell Migration ◽  
Intermediate Filaments ◽  
Cross Talk ◽  
Control Cell ◽  
The Novel ◽  
Mouse Development ◽  
Cytoskeleton Organization ◽  
Sprouting Angiogenesis ◽  
Promote Cell Migration ◽  
Necessary And Sufficient

Blood vessel formation requires endothelial cell (EC) migration that depends on dynamic remodeling of the cytoskeleton. Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein essential for EC migration and sprouting angiogenesis during mouse development and is implicated in metastatic disease. Here, we report that Rudhira mediates cytoskeleton organization and dynamics during EC migration. Rudhira binds to both microtubules (MTs) and vimentin intermediate filaments (IFs) and stabilizes MTs. Rudhira depletion impairs cytoskeletal cross-talk, MT stability, and hence focal adhesion disassembly. The BCAS3 domain of Rudhira is necessary and sufficient for MT-IF cross-linking and cell migration. Pharmacologically restoring MT stability rescues gross cytoskeleton organization and angiogenic sprouting in Rudhira-depleted cells. Our study identifies the novel and essential role of Rudhira in cytoskeletal cross-talk and assigns function to the conserved BCAS3 domain. Targeting Rudhira could allow tissue-restricted cytoskeleton modulation to control cell migration and angiogenesis in development and disease.

Sign in / Sign up

Export Citation Format

Share Document