High levels of antioxidant enzymatic defence assure good protection against hypoxic stress in spontaneously diabetic rats

2006 ◽  
Vol 38 (12) ◽  
pp. 2196-2208 ◽  
Author(s):  
A. Bonfigli ◽  
S. Colafarina ◽  
S. Falone ◽  
C. Di Giulio ◽  
C. Di Ilio ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Hypoxic Stress ◽  
Good Protection ◽  
Spontaneously Diabetic Rats

Endothelins urinary excretion is increased in spontaneously diabetic rats: BB/BB

Life Sciences ◽  
1994 ◽  
Vol 56 (1) ◽  
pp. PL13-PL18 ◽  
Author(s):  
E. Morabito ◽  
N. Corsico ◽  
E. Arrigoni Martelli
Keyword(s):  
Urinary Excretion ◽  
Diabetic Rats ◽  
Spontaneously Diabetic Rats

Sequential Morphological Changes in Pancreatic Islets of Spontaneously Diabetic Rats

Pancreas ◽  
1990 ◽  
Vol 5 (5) ◽  
pp. 533-539 ◽  
Author(s):  
César L. A. Gómez Dumm ◽  
Maria C. Semino ◽  
Juan Jose Gagliardino
Keyword(s):  
Pancreatic Islets ◽  
Morphological Changes ◽  
Diabetic Rats ◽  
Spontaneously Diabetic Rats

Altered regulation of cardiac glycogen metabolism in spontaneously diabetic rats

1983 ◽  
Vol 245 (4) ◽  
pp. E379-E383 ◽  
Author(s):  
T. B. Miller
Keyword(s):  
Glycogen Synthase ◽  
Glycogen Metabolism ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Metabolic Abnormalities ◽  
Insulin Deficiency ◽  
Kinase Activation ◽  
Chemically Induced ◽  
Spontaneously Diabetic Rats ◽  
Perfused Hearts

Isolated perfused hearts from control Bio-Breeding/Worcester (BB/W) rats and spontaneously diabetic BB/W rats were studied to determine whether metabolic abnormalities that are expressed in alloxan-diabetic rats in the regulation of enzymes involved in glycogen metabolism could be observed in this non-chemically induced insulin-deficient rat. Perfusion of hearts from control rats with 10(-8) M insulin for 10 min resulted in activation of glycogen synthase (30% synthase I without insulin to 44% synthase I with insulin). Perfusion of hearts from BB/W diabetic rats demonstrated a lack of acute synthase activation with insulin and a 45% decrease in synthase phosphatase activity. Perfusion of hearts from BB/W diabetic rats with 0.28 microM epinephrine for 1 min resulted in a greater activation of phosphorylase (44% phosphorylase a) than that observed in BB/W control hearts (31% phosphorylase a) perfused under the same conditions. Epinephrine produced similar changes in cyclic AMP accumulation, protein kinase activation, and phosphorylase kinase activation in perfused hearts of BB/W control and diabetic rats. Further, phosphorylase phosphatase activities were not changed by epinephrine or insulin deficiency. These studies further document metabolic abnormalities in the BB/W diabetic rat that are attributable to insulin deficiency in a non-chemically induced model for insulin-dependent diabetes.

Insulin metabolism by liver, muscle, and kidneys from spontaneously diabetic rats

1986 ◽  
Vol 250 (5) ◽  
pp. E530-E537
Author(s):  
R. Rabkin ◽  
G. M. Reaven ◽  
C. E. Mondon
Keyword(s):  
Diabetic Rats ◽  
Insulin Clearance ◽  
Immunoreactive Insulin ◽  
Insulin Metabolism ◽  
Complex Process ◽  
Consistent Manner ◽  
Liver And Kidney ◽  
Spontaneously Diabetic Rats ◽  
And Control

The in vivo metabolism of insulin is a complex process in which liver, kidney, and muscle are major participants. In this study we evaluated the effect of spontaneous hyperglycemic nonketoacidotic diabetes (DH) and ketoacidotic diabetes (DKA) on insulin clearance and degradation by these organs. Livers, hindlimbs, and kidneys from nondiabetic controls and DH and DKA Bio-Breed rats were isolated and perfused with artificial media. Liver clearance of immunoreactive insulin (ml/min) was significantly higher in DH rats, 6.0 +/- 0.2, but significantly lower in DKA rats, 3.4 +/- 0.5, compared with controls, 4.6 +/- 0.2. Acidosis alone induced by ammonium chloride loading, did not impair liver insulin clearance (4.8 +/- 0.4 ml/min). Muscle responded differently to the diabetic state in that insulin clearance was not altered by DH and DKA. Renal (organ) clearance of insulin was significantly depressed in the DKA state when compared with controls (0.52 +/- 0.04 and 0.75 +/- 0.07 ml X min-1 X g-1, respectively). This could largely be explained by a lower glomerular filtration rate. Fractional urinary insulin clearance was increased twofold above control values in DH kidneys and fourfold in DKA kidneys, indicating that tubular luminal absorption of insulin was impaired in both states. By contrast contraluminal uptake (peritubular clearance) did not differ significantly from controls. 125I-insulin degrading activity of the 100,000 g supernate fraction from muscle homogenates was similar in the diabetic and control groups. However in liver and kidney, degrading activity did not correspond to whole organ insulin clearance in a consistent manner.(ABSTRACT TRUNCATED AT 250 WORDS)

Upregulation of Retinal Vascular Endothelial Growth Factor mRNAs in Spontaneously Diabetic Rats without Ophthalmoscopic Retinopathy

1998 ◽  
Vol 30 (6) ◽  
pp. 333-339 ◽  
Author(s):  
Yasunori Segawa ◽  
Yutaka Shirao ◽  
Sho-ichi Yamagishi ◽  
Tomomi Higashide ◽  
Miho Kobayashi ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Diabetic Rats ◽  
Vascular Endothelial ◽  
Spontaneously Diabetic Rats ◽  
Endothelial Growth Factor

SPONTANEOUSLY DIABETIC RATS IN PRE-HYPERTENSIVE STAGE BENEFIT FROM OMEGA-3 FATTY ACIDS SUPPLEMENTATION: PP.17.141

2010 ◽  
Vol 28 ◽  
pp. e292-e293 ◽  
Author(s):  
J Radosinska ◽  
B Bacova ◽  
V Dosenko ◽  
H Lin ◽  
I Imanaga ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Diabetic Rats ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Spontaneously Diabetic Rats
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