Selective scavenging of intra-mitochondrial superoxide corrects diclofenac-induced mitochondrial dysfunction and gastric injury: A novel gastroprotective mechanism independent of gastric acid suppression

2016 ◽  
Vol 121 ◽  
pp. 33-51 ◽  
Author(s):  
Somnath Mazumder ◽  
Rudranil De ◽  
Souvik Sarkar ◽  
Asim Azhar Siddiqui ◽  
Shubhra Jyoti Saha ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Gastric Acid ◽  
Acid Suppression ◽  
Gastric Injury ◽  
Mitochondrial Superoxide ◽  
Gastric Acid Suppression

scholarly journals Gastric Enzyme Supplementation Inhibits Food Allergy in a BALB/c Mouse Model

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 738
Author(s):  
Nazanin Samadi ◽  
Denise Heiden ◽  
Martina Klems ◽  
Martina Salzmann ◽  
Johanna Rohrhofer ◽  
...  
Keyword(s):  
Food Allergy ◽  
Mouse Model ◽  
Gastric Acid ◽  
Clinical Symptoms ◽  
Acid Suppression ◽  
Gastric Digestion ◽  
Enzyme Solution ◽  
Allergic Symptoms ◽  
Gastric Acid Suppression ◽  
The Impact

Impaired gastric digestion due to suppressed gastric acidity enhances the risk for food allergy development. In the current study, we aimed to evaluate the impact of a supported gastric digestion via application of a pharmaceutical gastric enzyme solution (GES) on food allergy development and allergic reactions in a BALB/c mouse model. The ability of the GES to restore hypoacidic conditions was tested in mice treated with gastric acid suppression medication. To evaluate the impact on allergic symptoms, mice were orally sensitized with ovalbumin (OVA) under gastric acid suppression and subjected to oral challenges with or without GES. The immune response was evaluated by measurement of antibody titers, cytokine levels, mucosal allergy effector cell influx and regulatory T-cell counts. Clinical response was objectified by core body temperature measurements after oral OVA challenge. Supplementation of GES transiently restored physiological pH levels in the stomach after pharmaceutical gastric acid suppression. During oral sensitization, supplementation of gastric enzymes significantly reduced systemic IgE, IgG1 and IgG2a levels and allergic symptoms. In food allergic mice, clinical symptoms were reduced by co-administration of the gastric enzyme solution. Support of gastric digestion efficiently prevents food allergy induction and alleviates clinical symptoms in our food allergy model.

CLINICAL IMPACTS OF GASTRIC ACID SUPPRESSION THERAPY ON PATIENT WITH ADENOCARCINOMA OF LUNG TREATED WITH GEFITINIB

CHEST Journal ◽  
2019 ◽  
Vol 155 (4) ◽  
pp. 200A
Author(s):  
W.C. Kwok ◽  
J.C.M. Ho ◽  
L. David Chi Leung ◽  
M.M.S.L. Lui ◽  
M.S.M. Ip ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Acid Suppression ◽  
Acid Suppression Therapy ◽  
Adenocarcinoma Of Lung ◽  
Gastric Acid Suppression
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