Chk1 inhibitor synergizes quinacrine mediated apoptosis in breast cancer cells by compromising the base excision repair cascade

2016 ◽  
Vol 105 ◽  
pp. 23-33 ◽  
Author(s):  
Ranjan Preet ◽  
Sumit Siddharth ◽  
Shakti Ranjan Satapathy ◽  
Sarita Das ◽  
Anmada Nayak ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Base Excision Repair ◽  
Breast Cancer Cells ◽  
Excision Repair ◽  
Chk1 Inhibitor ◽  
Base Excision

scholarly journals Author response: Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

2019 ◽  
Author(s):  
Birong Shen ◽  
Joseph H Chapman ◽  
Michael F Custance ◽  
Gianna M Tricola ◽  
Charles E Jones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Base Excision Repair ◽  
Breast Cancer Cells ◽  
Excision Repair ◽  
Author Response ◽  
Base Excision

scholarly journals Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Birong Shen ◽  
Joseph H Chapman ◽  
Michael F Custance ◽  
Gianna M Tricola ◽  
Charles E Jones ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Base Excision Repair ◽  
Breast Cancer Cells ◽  
Excision Repair ◽  
Entry Site ◽  
Abasic Sites ◽  
Elevated Expression ◽  
Base Excision

Abundant APOBEC3 (A3) deaminase-mediated mutations can dominate the mutational landscape (‘mutator phenotype’) of some cancers, however, the basis of this sporadic vulnerability is unknown. We show here that elevated expression of the bifunctional DNA glycosylase, NEIL2, sensitizes breast cancer cells to A3B-mediated mutations and double-strand breaks (DSBs) by perturbing canonical base excision repair (BER). NEIL2 usurps the canonical lyase, APE1, at abasic sites in a purified BER system, rendering them poor substrates for polymerase β. However, the nicked NEIL2 product can serve as an entry site for Exo1 in vitro to generate single-stranded DNA, which would be susceptible to both A3B and DSBs. As NEIL2 or Exo1 depletion mitigates the DNA damage caused by A3B expression, we suggest that aberrant NEIL2 expression can explain certain instances of A3B-mediated mutations.

scholarly journals Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer

2014 ◽  
Vol 5 (2) ◽  
pp. e1076-e1076 ◽  
Author(s):  
S De Summa ◽  
R Pinto ◽  
B Pilato ◽  
D Sambiasi ◽  
L Porcelli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Base Excision Repair ◽  
Sporadic Breast Cancer ◽  
Excision Repair ◽  
Key Factors ◽  
Base Excision

scholarly journals Genetic Polymorphisms in Base-Excision Repair Pathway Genes and Risk of Breast Cancer

2006 ◽  
Vol 15 (2) ◽  
pp. 353-358 ◽  
Author(s):  
Yawei Zhang ◽  
Polly A. Newcomb ◽  
Kathleen M. Egan ◽  
Linda Titus-Ernstoff ◽  
Stephen Chanock ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Polymorphisms ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Repair Pathway ◽  
Base Excision Repair Pathway ◽  
Base Excision
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