Functional analysis of [methyl-3H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs

2014 ◽  
Vol 88 (3) ◽  
pp. 303-312 ◽  
Author(s):  
Chiaki Taguchi ◽  
Masato Inazu ◽  
Iwao Saiki ◽  
Miki Yara ◽  
Naomi Hara ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Functional Analysis ◽  
Nervous System ◽  
Choline Uptake ◽  
Glioblastoma Cells ◽  
Central Nervous System Drugs ◽  
Anti Cancer

scholarly journals Prospects for repurposing CNS drugs for cancer treatment

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Mohamed Abdelaleem ◽  
Hossam Ezzat ◽  
Muhammed Osama ◽  
Adel Megahed ◽  
Waleed Alaa ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Repurposing ◽  
New Approach ◽  
Central Nervous System Drugs ◽  
Anti Cancer ◽  
Cns Drugs ◽  
New Anticancer Drugs

Drug repurposing is the idea of using an already approved drug for another disease or disorder away from its initial use. This new approach ensures the reduction in high cost required for developing a new drug in addition to the time consumed, especially in the tumor disorders that show an unceasing rising rate with an unmet success rate of new anticancer drugs. In our review, we will review the anti-cancer effect of some CNS drugs, including both therapeutic and preventive, by searching the literature for preclinical or clinical evidence for anticancer potential of central nervous system drugs over the last 8 years period (2010-2018) and including only evidence from Q1 journals as indicated by Scimago website (www.scimagojr.com). We concluded that Some Central Nervous system drugs show a great potential as anti-cancer in vitro, in vivo and clinical trials through different mechanisms and pathways in different types of cancer that reveal a promising evidence for the repurposing of CNS drugs for new indications.

Central Nervous System Drugs

1987 ◽  
pp. 58-97
Author(s):  
J. M. Carney ◽  
H. D. Christensen ◽  
L. A. Reinke ◽  
L. E. Rikans
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Drugs

scholarly journals Membrane-type 1 Matrix Metalloprotease (MT1-MMP) Enables Invasive Migration of Glioma Cells in Central Nervous System White Matter

1999 ◽  
Vol 144 (2) ◽  
pp. 373-384 ◽  
Author(s):  
Ann T.J. Beliën ◽  
Paolo A. Paganetti ◽  
Martin E. Schwab
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
White Matter ◽  
Plasma Membranes ◽  
Malignant Gliomas ◽  
Glioma Cells ◽  
C6 Glioma ◽  
C6 Glioma Cells ◽  
Glioblastoma Cells

Invasive glioma cells migrate preferentially along central nervous system (CNS) white matter fiber tracts irrespective of the fact that CNS myelin contains proteins that inhibit cell migration and neurite outgrowth. Previous work has demonstrated that to migrate on a myelin substrate and to overcome its inhibitory effect, rat C6 and human glioblastoma cells require a membrane-bound metalloproteolytic activity (C6-MP) which shares several biochemical and pharmacological characteristics with MT1-MMP. We show now that MT1-MMP is expressed on the surface of rat C6 glioblastoma cells and is coenriched with C6-MP activity. Immunodepletion of C6-MP activity is achieved with an anti–MT1-MMP antibody. These data suggest that MT1-MMP and the C6-MP are closely related or identical. When mouse 3T3 fibroblasts were transfected with MT1-MMP they acquired the ability to spread and migrate on the nonpermissive myelin substrate and to infiltrate into adult rat optic nerve explants. MT1-MMP–transfected fibroblasts and C6 glioma cells were able to digest bNI-220, one of the most potent CNS myelin inhibitory proteins. Plasma membranes of both MT1-MMP–transfected fibroblasts and C6 glioma cells inactivated inhibitory myelin extracts, and this activity was sensitive to the same protease inhibitors. Interestingly, pretreatment of CNS myelin with gelatinase A/MMP-2 could not inactivate its inhibitory property. These data imply an important role of MT1-MMP in spreading and migration of glioma cells on white matter constituents in vitro and point to a function of MT1-MMP in the invasive behavior of malignant gliomas in the CNS in vivo.

Central nervous system drugs

Nursing ◽  
2019 ◽  
Vol 49 (3) ◽  
pp. 70
Author(s):  
Mary Barna Bridgeman ◽  
Kavitha S. Dalal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Drugs

RELATIONSHIP BETWEEN EXPOSURE AND NONSPECIFIC BINDING OF THIRTY-THREE CENTRAL NERVOUS SYSTEM DRUGS IN MICE

2004 ◽  
Vol 33 (1) ◽  
pp. 175-181 ◽  
Author(s):  
Tristan S. Maurer ◽  
Demetria B. DeBartolo ◽  
David A. Tess ◽  
Dennis O. Scott
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nonspecific Binding ◽  
Central Nervous System Drugs
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