The protective effect of Alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose

2012 ◽  
Vol 84 (7) ◽  
pp. 961-973 ◽  
Author(s):  
Lian-Qing Sun ◽  
Ying-Ying Chen ◽  
Xuan Wang ◽  
Xiao-Jin Li ◽  
Bing Xue ◽  
...  
Keyword(s):  
Protective Effect ◽  
Schwann Cells ◽  
Lipoic Acid ◽  
High Glucose ◽  
Alpha Lipoic Acid ◽  
Intermittent High Glucose

Effect of the alpha-lipoic acid on apoptosis in HIT-T15 cells induced by high glucose

2010 ◽  
Vol 34 (8) ◽  
pp. S14-S14
Author(s):  
Yi Yang ◽  
Wei‑Ping Wang ◽  
Yi‑Nan Liu ◽  
Ting Guo ◽  
Ping Chen ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
High Glucose ◽  
Alpha Lipoic Acid

scholarly journals Alpha-Lipoic Acid Alleviates High-Glucose Suppressed Osteogenic Differentiation of MC3T3-E1 Cells via Antioxidant Effect and PI3K/Akt Signaling Pathway

2017 ◽  
Vol 42 (5) ◽  
pp. 1897-1906 ◽  
Author(s):  
Kai Dong ◽  
Pengjie Hao ◽  
Sheng Xu ◽  
Shutai Liu ◽  
Wenjuan Zhou ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Osteogenic Differentiation ◽  
Lipoic Acid ◽  
High Glucose ◽  
Osteoblastic Differentiation ◽  
Antioxidant Effect ◽  
Akt Pathway ◽  
Alpha Lipoic Acid ◽  
Western Blots ◽  
Alizarin Red

Background/Aims: Patients with diabetes mellitus have a higher risk of dental implant failure. One major cause is high-glucose induced oxidative stress. Alpha-lipoic acid (ALA), a naturally occurring compound and dietary supplement, has been established as a potent antioxidant that is a strong scavenger of free radicals. However, few studies have yet investigated the effect of ALA on osteogenic differentiation of osteoblasts cultured with high glucose medium. The aim of this study is to investigate the effects of ALA on the osteoblastic differentiation in MC3T3-E1 cells under high glucose condition. Methods: MC3T3-E1 cells were divided into 4 groups including normal glucose (5.5 mM) group (control), high glucose (25.5 mM) group, high glucose + 0.1 mM ALA group, and high glucose + 0.2 mM ALA group. The proliferation, osteogenic differentiation and mineralization of cells were evaluated by MTT assay, alkaline phosphatase (ALP) activity assay, alizarin red staining and real time-polymerase chain reaction. High-glucose induced oxidative damage was also assessed by the production of reactive oxygen species (ROS) and superoxide dismutase (SOD). Western blots were performed to examine the role of PI3K/Akt pathway. Results: The proliferation, osteogenic differentiation and mineralization of MC3T3-E1 cells were significantly decreased by the ROS induced by high-glucose. All observed oxidative damage and osteogenic dysfunction induced were inhibited by ALA. Moreover, the PI3K/Akt pathway was activated by ALA. Conclusions: We demonstrate that ALA may attenuate high-glucose mediated MC3T3-E1 cells dysfunction through antioxidant effect and modulation of PI3K/Akt pathway.

The Protective Effect Of Alpha-Lipoic Acid On Ventilator And Lipopolysaccharide-Induced Lung Injury In Rats

2011 ◽  
Author(s):  
Hung Chang ◽  
Yu-Chien Kung ◽  
Shih-Chun Lee ◽  
Chung-Cheng Kao ◽  
Chia-Yu Chang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

Protective Effect of Alpha-lipoic Acid Against Lead Acetate-Induced Oxidative Stress in the Bone Marrow of Rats

2011 ◽  
Vol 7 (2) ◽  
pp. 217-227 ◽  
Author(s):  
Nagaraja Haleagraha ◽  
Tan Jackie ◽  
Srikumar Chakravart ◽  
Anupama Bangra Kulur
Keyword(s):  
Oxidative Stress ◽  
Bone Marrow ◽  
Protective Effect ◽  
Lipoic Acid ◽  
Lead Acetate ◽  
Alpha Lipoic Acid

Protective effect of alpha-lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

2016 ◽  
Vol 44 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Dilek Özbeyli ◽  
Ayşe Cansu Berberoglu ◽  
Anıl Özen ◽  
Oktay Erkan ◽  
Yunus Başar ◽  
...  
Keyword(s):  
Protective Effect ◽  
Resistance Exercise ◽  
Lipoic Acid ◽  
Second Hand Smoke ◽  
Alpha Lipoic Acid ◽  
Young Rats

scholarly journals Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats

2019 ◽  
Vol 10 ◽  
Author(s):  
Jia Jia ◽  
Xiaoying Gong ◽  
Yang Zhao ◽  
Zhenyu Yang ◽  
Kaiqiang Ji ◽  
...  
Keyword(s):  
Protective Effect ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid
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