Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: Potential mechanisms and functional consequences

Anjaneyulu Kowluru; Andrea Matti

doi:10.1016/j.bcp.2012.05.003

Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: Potential mechanisms and functional consequences

Biochemical Pharmacology ◽

10.1016/j.bcp.2012.05.003 ◽

2012 ◽

Vol 84 (5) ◽

pp. 591-597 ◽

Cited By ~ 45

Author(s):

Anjaneyulu Kowluru ◽

Andrea Matti

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Functional Consequences ◽

Phosphatase 2A

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Protein phosphatase 2A regulation of markers of extracellular matrix remodelling in hepatocellular carcinoma cells: functional consequences for tumour invasion

British Journal of Pharmacology ◽

10.1111/bph.13759 ◽

2017 ◽

Vol 174 (10) ◽

pp. 1116-1130 ◽

Cited By ~ 11

Author(s):

M P Ward ◽

J P Spiers

Keyword(s):

Hepatocellular Carcinoma ◽

Extracellular Matrix ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Carcinoma Cells ◽

Tumour Invasion ◽

Hepatocellular Carcinoma Cells ◽

Extracellular Matrix Remodelling ◽

Functional Consequences ◽

Phosphatase 2A

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Carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting cells: evidence for functional consequences on enzyme activity and insulin secretion.

Endocrinology ◽

10.1210/endo.137.6.8641181 ◽

1996 ◽

Vol 137 (6) ◽

pp. 2315-2323 ◽

Cited By ~ 34

Author(s):

A Kowluru ◽

S E Seavey ◽

M E Rabaglia ◽

R Nesher ◽

S A Metz

Keyword(s):

Enzyme Activity ◽

Insulin Secretion ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Catalytic Subunit ◽

Insulin Secreting Cells ◽

Functional Consequences ◽

Phosphatase 2A

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Auxin transportGarbers, C., DeLong, A., Deruére, J., Bernasconi, P. and Söll, D. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis, EMBO J. 15, 2115–2124

Trends in Plant Science ◽

10.1016/s1360-1385(96)86891-0 ◽

1996 ◽

Vol 1 (7) ◽

pp. 211-211

Keyword(s):

Protein Phosphatase ◽

Auxin Transport ◽

Protein Phosphatase 2A ◽

Regulatory Subunit ◽

Subunit A ◽

Phosphatase 2A

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Faculty Opinions recommendation of Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009236.125458 ◽

2002 ◽

Author(s):

Andreas Wodarz

Keyword(s):

Tight Junction ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Tight Junction Complex ◽

Atypical Pkc ◽

Phosphatase 2A ◽

Epithelial Tight Junction

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Faculty Opinions recommendation of Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012648.186405 ◽

2003 ◽

Author(s):

Martin A Schwartz

Keyword(s):

Protein Kinase ◽

Protein Phosphatase ◽

Protein Kinase B ◽

Protein Phosphatase 2A ◽

Local Activation ◽

Phosphatase 2A ◽

Beta1 Integrin

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Faculty Opinions recommendation of Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023795.367924 ◽

2006 ◽

Author(s):

Jonathan Millar

Keyword(s):

Sister Chromatid ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Sister Chromatid Cohesion ◽

Chromatid Cohesion ◽

Phosphatase 2A ◽

Meiosis I

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Faculty Opinions recommendation of Generation of active protein phosphatase 2A is coupled to holoenzyme assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087308.540326 ◽

2007 ◽

Author(s):

Ian Willis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Active Protein ◽

Phosphatase 2A

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Faculty Opinions recommendation of REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718505432.793499740 ◽

2014 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Mtorc1 Signaling ◽

Phosphatase 2A

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Faculty Opinions recommendation of The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7352956.10037054 ◽

2011 ◽

Author(s):

Philipp Kaldis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A ◽

Greatwall Kinase ◽

Inhibiting Protein

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Faculty Opinions recommendation of Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737780631.793577330 ◽

2020 ◽

Author(s):

Brion Murray

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A

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