The inhibitory glutathione transferase M2-2 binding site is located in divergent region 3 of the cardiac ryanodine receptor

2012 ◽  
Vol 83 (11) ◽  
pp. 1523-1529 ◽  
Author(s):  
Dan Liu ◽  
Ruwani Hewawasam ◽  
Yamuna Karunasekara ◽  
Marco G. Casarotto ◽  
Angela F. Dulhunty ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Glutathione Transferase ◽  
Divergent Region ◽  
Cardiac Ryanodine Receptor

The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

2010 ◽  
Vol 80 (3) ◽  
pp. 381-388 ◽  
Author(s):  
Ruwani Hewawasam ◽  
Dan Liu ◽  
Marco G. Casarotto ◽  
Angela F. Dulhunty ◽  
Philip G. Board
Keyword(s):  
Ryanodine Receptor ◽  
Glutathione Transferase ◽  
Helical Bundle ◽  
Cardiac Ryanodine Receptor

Role of Cys3602 in the function and regulation of the cardiac ryanodine receptor

2015 ◽  
Vol 467 (1) ◽  
pp. 177-190 ◽  
Author(s):  
Tao Mi ◽  
Zhichao Xiao ◽  
Wenting Guo ◽  
Yijun Tang ◽  
Florian Hiess ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Central Region ◽  
Calcium Release ◽  
Important Determinant ◽  
Cardiac Ryanodine Receptor

Cys3602 in cardiac ryanodine receptor (RyR) mediates the action of the thiol agent N-ethylmaleimide, but not 4,4′-dithiodipyridine (DTDP). A central region encompassing the calmodulin (CaM)-binding site and Cys3602 in cardiac RyR represents an important determinant of calcium-release activation and termination.

scholarly journals Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations

2014 ◽  
Vol 106 (2) ◽  
pp. 108a
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin C. Carlsson ◽  
Paolo A. Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Cardiac Ryanodine Receptor

scholarly journals The Cardiac Ryanodine Receptor N-Terminal Region Contains an Anion Binding Site that Is Targeted by Disease Mutations

Structure ◽  
2013 ◽  
Vol 21 (8) ◽  
pp. 1440-1449 ◽  
Author(s):  
Lynn Kimlicka ◽  
Ching-Chieh Tung ◽  
Anna-Carin Cecilia Carlsson ◽  
Paolo Antonio Lobo ◽  
Zhiguang Yuchi ◽  
...  
Keyword(s):  
Binding Site ◽  
Ryanodine Receptor ◽  
Terminal Region ◽  
Anion Binding ◽  
Disease Mutations ◽  
Cardiac Ryanodine Receptor

scholarly journals ARVC-Related Mutations in Divergent Region 3 Alter Functional Properties of the Cardiac Ryanodine Receptor

2008 ◽  
Vol 94 (12) ◽  
pp. 4668-4677 ◽  
Author(s):  
Andrea Koop ◽  
Petra Goldmann ◽  
S. R. Wayne Chen ◽  
Rolf Thieleczek ◽  
Magdolna Varsányi
Keyword(s):  
Ryanodine Receptor ◽  
Functional Properties ◽  
Divergent Region ◽  
Cardiac Ryanodine Receptor
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