scholarly journals The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids

2012 ◽  
Vol 83 (10) ◽  
pp. 1465-1473 ◽  
Author(s):  
Bertrand Grenier ◽  
Ana-Paula F.L. Bracarense ◽  
Heidi Elisabeth Schwartz ◽  
Catherine Trumel ◽  
Anne-Marie Cossalter ◽  
...  
Keyword(s):  
Fumonisin B1 ◽  
Hepatic Toxicity ◽  
Hydrolyzed Fumonisin

Hydrolyzed fumonisin B1 induces less inflammatory responses than fumonisin B1 in the co-culture model of porcine intestinal epithelial and immune cells

2019 ◽  
Vol 305 ◽  
pp. 110-116 ◽  
Author(s):  
Min Jeong Gu ◽  
Seung Eun Han ◽  
Kyoryen Hwang ◽  
Elisabeth Mayer ◽  
Nicole Reisinger ◽  
...  
Keyword(s):  
Immune Cells ◽  
Inflammatory Responses ◽  
Fumonisin B1 ◽  
Intestinal Epithelial ◽  
Culture Model ◽  
Hydrolyzed Fumonisin

scholarly journals Enzyme characteristics of aminotransferase FumI of Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin B1

2011 ◽  
Vol 91 (3) ◽  
pp. 757-768 ◽  
Author(s):  
Doris Hartinger ◽  
Heidi Schwartz ◽  
Christian Hametner ◽  
Gerd Schatzmayr ◽  
Dietmar Haltrich ◽  
...  
Keyword(s):  
Fumonisin B1 ◽  
Hydrolyzed Fumonisin

scholarly journals Excretion of14C-Fumonisin B1,14C-Hydrolyzed Fumonisin B1, and14C-Fumonisin B1-Fructose in Rats

1999 ◽  
Vol 47 (10) ◽  
pp. 4291-4296 ◽  
Author(s):  
William R. Dantzer ◽  
Joan Hopper ◽  
Kathy Mullin ◽  
Suzanne Hendrich ◽  
Patricia A. Murphy
Keyword(s):  
Fumonisin B1 ◽  
Hydrolyzed Fumonisin

Oxidative deamination of hydrolyzed fumonisin B1 (AP1) by cultures ofExophiala spinifera

1999 ◽  
Vol 7 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Barbara A. Blackwell ◽  
Jacob T. Gilliam ◽  
Marc E. Savard ◽  
J. David Miller ◽  
Jonathan P. Duvick
Keyword(s):  
Fumonisin B1 ◽  
Oxidative Deamination ◽  
Hydrolyzed Fumonisin

scholarly journals Enhancement of solubility in Escherichia coli and purification of an aminotransferase from Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin B1

2010 ◽  
Vol 9 (1) ◽  
pp. 62 ◽  
Author(s):  
Doris Hartinger ◽  
Stefan Heinl ◽  
Heidi Schwartz ◽  
Reingard Grabherr ◽  
Gerd Schatzmayr ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Fumonisin B1 ◽  
Hydrolyzed Fumonisin

scholarly journals Toxicokinetics of Hydrolyzed Fumonisin B1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet

Toxins ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 413 ◽  
Author(s):  
Gunther Antonissen ◽  
Siegrid De Baere ◽  
Barbara Novak ◽  
Dian Schatzmayr ◽  
Danica den Hollander ◽  
...  
Keyword(s):  
Oral Administration ◽  
Broiler Chickens ◽  
Clinical Symptoms ◽  
Control Diet ◽  
Plasma Concentrations ◽  
Fumonisin B1 ◽  
Ultra Performance Liquid Chromatography ◽  
Limit Of Quantification ◽  
Liquid Chromatography Tandem Mass ◽  
Hydrolyzed Fumonisin

The toxicokinetics (TK) of hydrolyzed fumonisin B1 (HFB1) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-contaminated diet (10.8 mg fumonisin B1, 3.3 mg B2 and 1.5 mg B3/kg feed) for two weeks, followed by a single oral (PO) or intravenous (IV) dose of 1.25 mg/kg bodyweight (BW) of HFB1. Fumonisin B1 (FB1), its partially hydrolyzed metabolites pHFB1a and pHFB1b, and fully hydrolyzed metabolite HFB1, were determined in chicken plasma using a validated ultra-performance liquid chromatography–tandem mass spectrometry method. None of the broiler chicken showed clinical symptoms of fumonisins (FBs) or HFB1 toxicity during the trial, nor was an aberration in body weight observed between the animals fed the FBs-contaminated diet and those fed the control diet. HFB1 was shown to follow a two-compartmental pharmacokinetic model with first order elimination in broiler chickens after IV administration. Toxicokinetic parameters of HFB1 demonstrated a total body clearance of 16.39 L/kg·h and an intercompartmental flow of 8.34 L/kg·h. Low levels of FB1 and traces of pHFB1b were found in plasma of chickens fed the FBs-contaminated diet. Due to plasma concentrations being under the limit of quantification (LOQ) after oral administration of HFB1, no toxicokinetic modelling could be performed in broiler chickens after oral administration of HFB1. Moreover, no phase II metabolites, nor N-acyl-metabolites of HFB1 could be detected in this study.

A preliminary investigation on renal and hepatic toxicity in rats fed purified fumonisin B1

1993 ◽  
Vol 1 (4) ◽  
pp. 222-228 ◽  
Author(s):  
Kenneth A. Voss ◽  
William J. Chamberlain ◽  
Charles W. Bacon ◽  
William P. Norred
Keyword(s):  
Preliminary Investigation ◽  
Fumonisin B1 ◽  
Hepatic Toxicity

An aminotransferase from bacterium ATCC 55552 deaminates hydrolyzed fumonisin B1

2010 ◽  
Vol 22 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Stefan Heinl ◽  
Doris Hartinger ◽  
Michaela Thamhesl ◽  
Gerd Schatzmayr ◽  
Wulf-Dieter Moll ◽  
...  
Keyword(s):  
Fumonisin B1 ◽  
Hydrolyzed Fumonisin
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