Hepatocyte growth factor suppresses the anticancer effect of irinotecan by decreasing the level of active metabolite in HepG2 cells

2011 ◽  
Vol 82 (11) ◽  
pp. 1720-1730 ◽  
Author(s):  
Manabu Okumura ◽  
Tomomi Iwakiri ◽  
Akinori Takagi ◽  
Yasutoshi Hirabara ◽  
Yohei Kawano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepg2 Cells ◽  
Active Metabolite ◽  
Anticancer Effect ◽  
Hepatocyte Growth

scholarly journals Enhancement of Hepatocyte Growth Factor-Induced Cell Scattering in N-Acetylglucosaminyltransferase III-transfected HepG2 Cells

2004 ◽  
Vol 27 (6) ◽  
pp. 781-785 ◽  
Author(s):  
Masashi Hyuga ◽  
Sumiko Hyuga ◽  
Nana Kawasaki ◽  
Miyako Ohta ◽  
Satsuki Itoh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepg2 Cells ◽  
Cell Scattering ◽  
Hepatocyte Growth

scholarly journals Down-regulation of CMTM8 Induces Epithelial-to-Mesenchymal Transition-like Changes via c-MET/Extracellular Signal-regulated Kinase (ERK) Signaling

2012 ◽  
Vol 287 (15) ◽  
pp. 11850-11858 ◽  
Author(s):  
Wenjuan Zhang ◽  
Michelle C. Mendoza ◽  
Xiaolei Pei ◽  
Didem Ilter ◽  
Sarah J. Mahoney ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tumor Cell ◽  
Hepg2 Cells ◽  
Epithelial To Mesenchymal Transition ◽  
Mapk Pathway ◽  
Cellular Transformation ◽  
Down Regulation ◽  
Mesenchymal Transition ◽  
Hepatocyte Growth

The acquisition of an invasive phenotype is a critical turning point for malignant tumor cells. CMTM8, a potential tumor suppressor, is frequently down-regulated in solid tumors, and its overexpression induces tumor cell apoptosis. Here, we identify a new role for CMTM8 in regulating tumor cell migration. Reducing CMTM8 expression in HepG2 hepatocellular carcinoma cells results in the acquisition of epithelial-to-mesenchymal transition (EMT) features, including a morphological change from organized epithelial sheets to scattered fibroblast-like shapes, reduction of the epithelial marker E-cadherin, and an increased invasive and migratory ability. These phenotypic changes are mediated in large part by the ERK-MAPK pathway, as the MEK inhibitor U0126 and shRNA-mediated knockdown of ERK2 significantly reversed these phenotypes. Hepatocyte growth factor binding to the c-MET receptor is known to induce EMT in HepG2 cells. We found that CMTM8 knockdown in HepG2 cells induced c-MET signaling and ERK activation. Inhibition of c-MET signaling with the small molecule inhibitor SU11274 or c-MET RNAi blocked the EMT-like changes following CMTM8 knockdown. CMTM8 overexpression in HepG2 cells inhibited hepatocyte growth factor-induced EMT-like morphological changes and cell motility. Down-regulation of CMTM8 also promoted an EMT-like change in MCF-10A cells, indicating a broader role for CMTM8 in regulating cellular transformation.

TRPV channels and modulation by hepatocyte growth factor/scatter factor in human hepatoblastoma (HepG2) cells

Cell Calcium ◽  
2004 ◽  
Vol 36 (1) ◽  
pp. 19-28 ◽  
Author(s):  
Joris Vriens ◽  
Annelies Janssens ◽  
Jean Prenen ◽  
Bernd Nilius ◽  
Robert Wondergem
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepg2 Cells ◽  
Scatter Factor ◽  
Trpv Channels ◽  
Hepatocyte Growth

scholarly journals Tivantinib Decreases Hepatocyte Growth Factor-Induced BCRP Expression in Hepatocellular Carcinoma HepG2 Cells

2020 ◽  
Vol 43 (9) ◽  
pp. 1421-1425
Author(s):  
Kojiro Kobayashi ◽  
Koji Higai ◽  
Takanori Mukozu ◽  
Daigo Matsui ◽  
Makoto Amanuma ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepg2 Cells ◽  
Hepatocyte Growth

Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor

1998 ◽  
Vol 177 (1) ◽  
pp. 130-136 ◽  
Author(s):  
Nobuyuki Shima ◽  
Donna Beer Stolz ◽  
Masahiro Miyazaki ◽  
Eiichi Gohda ◽  
Kanji Higashio ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Growth Inhibition ◽  
Hepg2 Cells ◽  
P21 Waf1 ◽  
Hepatocyte Growth

scholarly journals Involvement of hepatocyte growth factor in increased integrin expression on HepG2 cells triggered by adhesion to endothelial cells

1997 ◽  
Vol 75 (1) ◽  
pp. 47-53 ◽  
Author(s):  
N Kawakami-Kimura ◽  
T Narita ◽  
K Ohmori ◽  
T Yoneda ◽  
K Matsumoto ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Hepg2 Cells ◽  
Integrin Expression ◽  
Hepatocyte Growth
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