scholarly journals Interplay between Ret and Fap-1 regulates CD95-mediated apoptosis in medullary thyroid cancer cells

2011 ◽  
Vol 82 (7) ◽  
pp. 778-788 ◽  
Author(s):  
Valentina Nicolini ◽  
Giuliana Cassinelli ◽  
Giuditta Cuccuru ◽  
Italia Bongarzone ◽  
Giovanna Petrangolini ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells

scholarly journals The RET Kinase Inhibitor NVP-AST487 Blocks Growth and Calcitonin Gene Expression through Distinct Mechanisms in Medullary Thyroid Cancer Cells

2007 ◽  
Vol 67 (14) ◽  
pp. 6956-6964 ◽  
Author(s):  
Nagako Akeno-Stuart ◽  
Michelle Croyle ◽  
Jeffrey A. Knauf ◽  
Roberta Malaguarnera ◽  
Donata Vitagliano ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Kinase Inhibitor ◽  
Medullary Thyroid ◽  
Calcitonin Gene ◽  
Thyroid Cancer Cells

scholarly journals PROX1 Promotes Secretory Granule Formation in Medullary Thyroid Cancer Cells

Endocrinology ◽  
2016 ◽  
Vol 157 (3) ◽  
pp. 1289-1298 ◽  
Author(s):  
Jun Ishii ◽  
Takuya Yazawa ◽  
Tomohiro Chiba ◽  
Yukiko Shishido-Hara ◽  
Yuu Arimasu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Papillary Thyroid Cancer ◽  
Secretory Granule ◽  
Chromogranin A ◽  
Medullary Thyroid Cancer ◽  
C Cells ◽  
Papillary Thyroid ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells

Abstract Mechanisms of endocrine secretory granule (SG) formation in thyroid C cells and medullary thyroid cancer (MTC) cells have not been fully elucidated. Here we directly demonstrated that PROX1, a developmental homeobox gene, is transcriptionally involved in SG formation in MTC, which is derived from C cells. Analyses using gene expression databases on web sites revealed that, among thyroid cancer cells, MTC cells specifically and highly express PROX1 as well as several SG-forming molecule genes. Immunohistochemical analyses showed that in vivo MTC and C cells expressed PROX1, although follicular thyroid cancer and papillary thyroid cancer cells, normal follicular cells did not. Knockdown of PROX1 in an MTC cells reduced SGs detected by electron microscopy, and decreased expression of SG-related genes (chromogranin A, chromogranin B, secretogranin II, secretogranin III, synaptophysin, and carboxypeptidase E). Conversely, the introduction of a PROX1 transgene into a papillary thyroid cancer and anaplastic thyroid cancer cells induced the expression of SG-related genes. Reporter assays using the promoter sequence of chromogranin A showed that PROX1 activates the chromogranin A gene in addition to the known regulatory mechanisms, which are mediated via the cAMP response element binding protein and the repressor element 1-silencing transcription factor. Furthermore, chromatin immunoprecipitation-PCR assays demonstrated that PROX1 binds to the transcriptional regulatory element of the chromogranin A gene. In conclusion, PROX1 is an important regulator of endocrine SG formation in MTC cells.

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells

Surgery ◽  
2003 ◽  
Vol 134 (6) ◽  
pp. 866-871 ◽  
Author(s):  
Rebecca S Sippel ◽  
Jennifer E Carpenter ◽  
Muthusamy Kunnimalaiyaan ◽  
Herbert Chen
Keyword(s):  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells

scholarly journals Valproic Acid Activates Notch1 Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells

2008 ◽  
Vol 247 (6) ◽  
pp. 1036-1040 ◽  
Author(s):  
David Yu Greenblatt ◽  
Max A. Cayo ◽  
Joel T. Adler ◽  
Li Ning ◽  
Megan R. Haymart ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Thyroid Cancer ◽  
Cancer Cells ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Notch1 Signaling ◽  
Thyroid Cancer Cells

RET signals through focal adhesion kinase in medullary thyroid cancer cells

Surgery ◽  
2004 ◽  
Vol 136 (6) ◽  
pp. 1212-1217 ◽  
Author(s):  
Ganesh R. Panta ◽  
Fiemu Nwariaku ◽  
Lawrence T. Kim
Keyword(s):  
Thyroid Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Medullary Thyroid Cancer ◽  
Medullary Thyroid ◽  
Thyroid Cancer Cells
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