2′,4′,6′-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-α-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways

2007 ◽  
Vol 74 (6) ◽  
pp. 870-880 ◽  
Author(s):  
Sung Hee Lee ◽  
Dong Hwan Sohn ◽  
Xing Yu Jin ◽  
Sang Wook Kim ◽  
Suck Chei Choi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Sulfonic Acid ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Heme Oxygenase 1 ◽  
Trinitrobenzene Sulfonic Acid ◽  
Intestinal Epithelial ◽  
Factor Α ◽  
Epithelial Inflammation ◽  
Necrosis Factor

scholarly journals Activation of muscarinic cholinoceptor ameliorates tumor necrosis factor-α-induced barrier dysfunction in intestinal epithelial cells

FEBS Letters ◽  
2015 ◽  
Vol 589 (23) ◽  
pp. 3640-3647 ◽  
Author(s):  
Md Rafiqul Islam Khan ◽  
Junsuke Uwada ◽  
Takashi Yazawa ◽  
Md Tariqul Islam ◽  
Susanne M. Krug ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Barrier Dysfunction ◽  
Factor Α ◽  
Necrosis Factor

Developmentally regulated tumor necrosis factor-α induced nuclear factor-κB activation in intestinal epithelium

2007 ◽  
Vol 292 (5) ◽  
pp. G1411-G1419 ◽  
Author(s):  
Erika C. Claud ◽  
Xiaoqiong Zhang ◽  
Elaine O. Petrof ◽  
Jun Sun
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intestinal Epithelial Cells ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Intestinal Epithelial ◽  
Factor Α ◽  
Necrosis Factor

Premature infants are susceptible to many conditions that are inflammatory in nature. For this patient population, which is expecting the intrauterine environment, pathways necessary for fetal life and development may not have completed the transitions necessary for extrauterine life. In this study, responses to tumor necrosis factor-α were compared in human fetal and adult intestinal epithelial cell lines along with preweaned and postweaned mouse intestinal sections to identify a potential developmental difference that may explain the heightened inflammatory response of preterm infants. The nuclear factor-κB (NF-κB) pathway regulates a wide variety of genes involved in immune and inflammatory processes. We report that, compared with adult intestinal epithelial cells, immature intestinal epithelial cells have increased NF-κB activity associated with increased NF-κB-DNA binding and transcriptional activity. This increased activity appears due to inadequate inhibition of signaling leading to NF-κB activation since there is also increased phosphorylation, ubiquitination, and degradation of the inhibitor of NF-κB in conjunction with decreased baseline expression and delayed resynthesis of this inhibitor. Thus we demonstrate a potential mechanism for the heightened inflammatory response of immature intestinal epithelial cells.

scholarly journals Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription

2017 ◽  
Vol 5 (19) ◽  
pp. e13451 ◽  
Author(s):  
Michael A. Peplowski ◽  
Andrew J. Vegso ◽  
Vadim Iablokov ◽  
Michael Dicay ◽  
Raza S. Zaheer ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Epithelial Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Aquaporin 3 ◽  
Factor Α ◽  
Necrosis Factor
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