Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice

2007 ◽  
Vol 73 (1) ◽  
pp. 136-146 ◽  
Author(s):  
Na Lin ◽  
Chunfang Liu ◽  
Cheng Xiao ◽  
Hongwei Jia ◽  
Keisuke Imada ◽  
...  
Keyword(s):  
Cartilage Destruction ◽  
Collagen Induced Arthritis ◽  
And Cartilage

scholarly journals Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction

1998 ◽  
Vol 41 (1) ◽  
pp. 110-121 ◽  
Author(s):  
J. S. Mudgett ◽  
N. I. Hutchinson ◽  
N. A. Chartrain ◽  
A. J. Forsyth ◽  
J. McDonnell ◽  
...  
Keyword(s):  
Cartilage Destruction ◽  
Collagen Induced Arthritis ◽  
Deficient Mice ◽  
And Cartilage

scholarly journals Managing Osteoporosis and Joint Damage in Patients with Rheumatoid Arthritis: An Overview

2021 ◽  
Vol 10 (6) ◽  
pp. 1241
Author(s):  
Yoshiya Tanaka
Keyword(s):  
Rheumatoid Arthritis ◽  
Structural Damage ◽  
Kinase Inhibitors ◽  
Joint Destruction ◽  
Joint Damage ◽  
Nuclear Factor Κb ◽  
Cartilage Destruction ◽  
Janus Kinase ◽  
Systemic Autoimmune Disease ◽  
And Cartilage

In rheumatoid arthritis, a representative systemic autoimmune disease, immune abnormality and accompanying persistent synovitis cause bone and cartilage destruction and systemic osteoporosis. Biologics targeting tumor necrosis factor, which plays a central role in the inflammatory process, and Janus kinase inhibitors have been introduced in the treatment of rheumatoid arthritis, making clinical remission a realistic treatment goal. These drugs can prevent structural damage to bone and cartilage. In addition, osteoporosis, caused by factors such as menopause, aging, immobility, and glucocorticoid use, can be treated with bisphosphonates and the anti-receptor activator of the nuclear factor-κB ligand antibody. An imbalance in the immune system in rheumatoid arthritis induces an imbalance in bone metabolism. However, osteoporosis and bone and cartilage destruction occur through totally different mechanisms. Understanding the mechanisms underlying osteoporosis and joint destruction in rheumatoid arthritis leads to improved care and the development of new treatments.

scholarly journals Xianfanghuomingyin, a Chinese Compound Medicine, Modulates the Proliferation and Differentiation of T Lymphocyte in a Collagen-Induced Arthritis Mouse Model

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Bo Nie ◽  
Xue Li ◽  
Yi Wei ◽  
Meng Chen ◽  
Jingwei Zhou ◽  
...  
Keyword(s):  
Mouse Model ◽  
Th17 Cells ◽  
Retinoic Acid Receptor ◽  
Treg Cells ◽  
Immunological Tolerance ◽  
Cartilage Destruction ◽  
Orphan Receptor ◽  
Th2 Cells ◽  
Collagen Induced Arthritis ◽  
Proliferation And Differentiation

In traditional Chinese medicine (TCM), xianfanghuomingyin (XFHM) is used to treat autoimmune diseases, including rheumatoid arthritis (RA). Here, we studied the mechanisms underlying its treatment effects, especially its anti-inflammatory effects in a collagen-induced arthritis (CIA) mouse model. We found that cartilage destruction and pannus formation were alleviated by treatment with XFHM. The abnormal differentiation of Th1 and Th17 cells was downregulated significantly by XFHM, and Th2 and Treg cells were upregulated. Moreover, the expression levels of specific cytokines and transcription factors related to Th1 cells (interferonγ[IFNγ], T-bet) and Th17 cells (interleukin- [IL-] 17) and the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORγ) were downregulated. Serum IL-4 and GATA-3, which contribute to Th2 cells differentiation, increased significantly after XFHM administration. These results indicate that XFHM can restore the balance of T lymphocytes and reestablish the immunological tolerance to inhibit autoinflammatory disorder of RA. Taken together, XFHM can be used as a complementary or alternative traditional medicine to treat RA.

scholarly journals Prostaglandins and Rheumatoid Arthritis

Arthritis ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad Javad Fattahi ◽  
Abbas Mirshafiey
Keyword(s):  
Rheumatoid Arthritis ◽  
Arachidonic Acid ◽  
Immune Responses ◽  
Cartilage Destruction ◽  
Heterogeneous Population ◽  
Therapeutic Protocol ◽  
Site Of Action ◽  
And Cartilage ◽  
Homeostatic Mechanisms

Rheumatoid arthritis (RA) is a chronic, autoimmune, and complex inflammatory disease leading to bone and cartilage destruction, whose cause remains obscure. Accumulation of genetic susceptibility, environmental factors, and dysregulated immune responses are necessary for mounting this self-reacting disease. Inflamed joints are infiltrated by a heterogeneous population of cellular and soluble mediators of the immune system, such as T cells, B cells, macrophages, cytokines, and prostaglandins (PGs). Prostaglandins are lipid inflammatory mediators derived from the arachidonic acid by multienzymatic reactions. They both sustain homeostatic mechanisms and mediate pathogenic processes, including the inflammatory reaction. They play both beneficial and harmful roles during inflammation, according to their site of action and the etiology of the inflammatory response. With respect to the role of PGs in inflammation, they can be effective mediators in the pathophysiology of RA. Thus the use of agonists or antagonists of PG receptors may be considered as a new therapeutic protocol in RA. In this paper, we try to elucidate the role of PGs in the immunopathology of RA.

scholarly journals Absence of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling protects against collagen-induced arthritis

2013 ◽  
Vol 74 (1) ◽  
pp. 211-219 ◽  
Author(s):  
M I P Ramos ◽  
O N Karpus ◽  
P Broekstra ◽  
S Aarrass ◽  
S E Jacobsen ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Acute Phase ◽  
Ex Vivo ◽  
Late Phase ◽  
Joint Destruction ◽  
Chronic Phase ◽  
Foxp3 Expression ◽  
Cartilage Destruction ◽  
Collagen Induced Arthritis ◽  
Clinical Arthritis

ObjectiveComprehending the mechanisms that regulate activation of autoreactive T cells and B cell antibody production is fundamental for understanding the breakdown in self-tolerance and development of autoimmunity. Here we studied the role of Fms-like tyrosine kinase 3 ligand (Flt3L) signalling in the pathogenesis of collagen-induced arthritis (CIA).MethodsCIA was induced in mice lacking Flt3L (Flt3L−/−)and wild-type (WT) littermates (C57/BL6, 8–10 weeks old). Mice were killed in the initial phase (acute phase: experiment 1) and late phase (chronic phase: experiment 2) of the disease. Arthritis severity was assessed using a semiquantitative scoring system (0–4), and histological analysis of cellular infiltration, cartilage destruction and peptidoglycan loss was performed. Phenotypic and functional analysis of T and B cells, FoxP3 expression, activation and lymphocyte costimulatory markers, and cytokine production were performed ex vivo by flow cytometry in lymph nodes. Serum collagen type II (CII)-specific antibodies were measured by ELISA.ResultsFlt3L−/−mice showed a marked decrease in clinical arthritis scores and incidence of arthritis in both acute and chronic phases of CIA compared with WT mice. Moreover, decreased synovial inflammation and joint destruction was observed. Both the magnitude and quality of T cell responses were altered in Flt3L−/−. In the acute phase, the amount of CII-specific IgG2a antibodies was lower in Flt3L−/−than WT mice.ConclusionsThese results strongly suggest a role for Flt3L signalling in the development of arthritis.

scholarly journals Membrane-Associated IL-1 Contributes to Chronic Synovitis and Cartilage Destruction in Human IL-1α Transgenic Mice

2003 ◽  
Vol 172 (1) ◽  
pp. 577-584 ◽  
Author(s):  
Yasuo Niki ◽  
Harumoto Yamada ◽  
Toshiyuki Kikuchi ◽  
Yoshiaki Toyama ◽  
Hideo Matsumoto ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cartilage Destruction ◽  
Chronic Synovitis ◽  
And Cartilage

scholarly journals Role of Activatory FcγRI and FcγRIII and Inhibitory FcγRII in Inflammation and Cartilage Destruction during Experimental Antigen-Induced Arthritis

2001 ◽  
Vol 159 (6) ◽  
pp. 2309-2320 ◽  
Author(s):  
Peter L.E.M. Van Lent ◽  
Karin Nabbe ◽  
Arjen B. Blom ◽  
Astrid E.M. Holthuysen ◽  
Annet Sloetjes ◽  
...  
Keyword(s):  
Cartilage Destruction ◽  
And Cartilage

A MULTIMODAL IMAGING MODALITY FOR UNDERSTANDING BONE AND CARTILAGE DESTRUCTION AND REPAIR IN RHEUMATOID ARTHRITIS

2008 ◽  
Vol 41 ◽  
pp. S189
Author(s):  
Kathryn Stok ◽  
Danièle Noël ◽  
Florence Apparailly ◽  
David Gould ◽  
Yuti Chernajovsky ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Multimodal Imaging ◽  
Imaging Modality ◽  
Cartilage Destruction ◽  
And Cartilage
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