Inhibitory effects of epicatechin on interleukin-1β-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-κB activation

2004 ◽  
Vol 68 (9) ◽  
pp. 1775-1785 ◽  
Author(s):  
Myung-Jun Kim ◽  
Gyeong Ryul Ryu ◽  
Jung-Hoon Kang ◽  
Sang Soo Sim ◽  
Do Sik Min ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Pancreatic Islets ◽  
Inducible Nitric Oxide Synthase ◽  
Interleukin 1Β ◽  
Inhibitory Effects ◽  
Rinm5f Cells ◽  
Rat Pancreatic Islets ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Vasculoprotective Role of Inducible Nitric Oxide Synthase at Inflammatory Coronary Lesions Induced by Chronic Treatment With Interleukin-1β in Pigs in Vivo

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3104-3111 ◽  
Author(s):  
Yoshihiro Fukumoto ◽  
Hiroaki Shimokawa ◽  
Toshiyuki Kozai ◽  
Toshiaki Kadokami ◽  
Kouichi Kuwata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chronic Treatment ◽  
Interleukin 1Β ◽  
Coronary Lesions ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Effects of Cisplatin Administration on the Inducible Nitric Oxide Synthase and Somatostatin in the Pancreatic Islets

1997 ◽  
Vol 3 (S2) ◽  
pp. 163-164
Author(s):  
Ying Wang ◽  
Surinder K. Aggarwal
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Pancreatic Islets ◽  
Inducible Nitric Oxide Synthase ◽  
Clinical Situation ◽  
Severe Nausea ◽  
Before And After ◽  
Cancer Agent ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Cisplatin, a potent broad spectrum anti-cancer agent, has been proven effective in the treatments of bladder, lung, ovarian, head and neck, and testicular cancers. Drawbacks of this chemotherapeutic drug are its toxic side-effects, which include severe nausea, vomiting, stomach distention, peptic ulcer and hyperglycemia. Cisplatin treatment induces the hyperglycemia both in clinical situation and the rodents. Because of the role of the inducible nitric oxide synthase (i-NOS) and somatostatin on the dysfunction of the β-cell of the pancreatic islets and the suppression of the insulin secretion, these were studied using immunocytochemical methods before and after cisplatin treatments using rats.Wistar rats (100-150 g) were divided into two groups of 6 animals each. One group received injections of cisplatin (9 mg/kg) in 0.85% saline in 5 divided dosages over a 5 days period. The other group received the vehicle of injection only. Rats were killed one day after the last injection.

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