The role of n-3 dietary polyunsaturated fatty acids in brain function and ameliorating Alzheimer's disease: Opportunities for biotechnology in the development of nutraceuticals

2012 ◽  
Vol 1 (2) ◽  
pp. 159-166 ◽  
Author(s):  
Agnieszka M. Falinska ◽  
Cécile Bascoul-Colombo ◽  
Irina A. Guschina ◽  
Mark Good ◽  
John L. Harwood
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Brain Function ◽  
Dietary Polyunsaturated Fatty Acids

The protective role of endogenous n-3 polyunsaturated fatty acids in Tau Alzheimer’s disease mouse model

2018 ◽  
Vol 129 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Guang Fang ◽  
Baoyan Shi ◽  
Kefeng Wu ◽  
Siyu Chen ◽  
Xiang Gao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Mouse Model ◽  
Polyunsaturated Fatty Acids ◽  
Protective Role

Possible Role of S-Adenosylmethionine, S-Adenosylhomocysteine, and Polyunsaturated Fatty Acids in Predementia Syndromes and Alzheimer's Disease

2009 ◽  
Vol 16 (3) ◽  
pp. 467-470 ◽  
Author(s):  
Francesco Panza ◽  
Vincenza Frisardi ◽  
Cristiano Capurso ◽  
Alessia D'Introno ◽  
Anna M. Colacicco ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Predementia Syndromes

THE RELATIONSHIP OF OMEGA 3 POLYUNSATURATED FATTY ACIDS IN RED BLOOD CELL MEMBRANES WITH COGNITIVE FUNCTION AND BRAIN STRUCTURE: A REVIEW FOCUSSED ON ALZHEIMER’S DISEASE

2017 ◽  
pp. 1-7
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Blood Cell ◽  
Polyunsaturated Fatty Acids ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Research Attention ◽  
Pufa Supplementation

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci

scholarly journals Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1382
Author(s):  
Fabien Pifferi ◽  
Stephen C. Cunnane ◽  
Philippe Guesnet
Keyword(s):  
Fatty Acids ◽  
Glucose Metabolism ◽  
Polyunsaturated Fatty Acids ◽  
Brain Function ◽  
High Energy ◽  
Brain Glucose ◽  
Brain Glucose Metabolism ◽  
Age Related ◽  
The Brain

In mammals, brain function, particularly neuronal activity, has high energy needs. When glucose is supplemented by alternative oxidative substrates under different physiological conditions, these fuels do not fully replace the functions fulfilled by glucose. Thus, it is of major importance that the brain is almost continuously supplied with glucose from the circulation. Numerous studies describe the decrease in brain glucose metabolism during healthy or pathological ageing, but little is known about the mechanisms that cause such impairment. Although it appears difficult to determine the exact role of brain glucose hypometabolism during healthy ageing or during age-related neurodegenerative diseases such as Alzheimer’s disease, uninterrupted glucose supply to the brain is still of major importance for proper brain function. Interestingly, a body of evidence suggests that dietary n-3 polyunsaturated fatty acids (PUFAs) might play significant roles in brain glucose regulation. Thus, the goal of the present review is to summarize this evidence and address the role of n-3 PUFAs in brain energy metabolism. Taken together, these data suggest that ensuring an adequate dietary supply of n-3 PUFAs could constitute an essential aspect of a promising strategy to promote optimal brain function during both healthy and pathological ageing.

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids

2015 ◽  
Vol 6 (4) ◽  
pp. 1251-1260 ◽  
Author(s):  
Laura Fernández-Fernández ◽  
Gerard Esteban ◽  
Mercedes Giralt ◽  
Tony Valente ◽  
Irene Bolea ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Mouse Brain ◽  
Cognitive Reserve ◽  
Disease Risk ◽  
Cholinergic Systems

LMN diet could benefit the cognitive reserve reducing Alzheimer's disease risk.

scholarly journals Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease

FEBS Journal ◽  
2017 ◽  
Vol 284 (23) ◽  
pp. 4083-4095 ◽  
Author(s):  
Ahmed Elharram ◽  
Nicole M. Czegledy ◽  
Michael Golod ◽  
Ginger L. Milne ◽  
Erik Pollock ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Mouse Model ◽  
Polyunsaturated Fatty Acids ◽  
Sporadic Alzheimer’S Disease
Sign in / Sign up

Export Citation Format

Share Document