Ivabradine inhibits the production of proinflammatory cytokines and inducible nitric oxide synthase in acute coxsackievirus B3-induced myocarditis

2013 ◽  
Vol 431 (3) ◽  
pp. 450-455 ◽  
Author(s):  
Yue-Chun Li ◽  
Qin Luo ◽  
Li-Sha Ge ◽  
Yi-He Chen ◽  
Na-Dan Zhou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Proinflammatory Cytokines ◽  
Coxsackievirus B3 ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

In Situ Detection of Inflammatory Cytokines and Apoptosis in Pemphigus Foliaceus Patients

2009 ◽  
Vol 133 (1) ◽  
pp. 97-100
Author(s):  
Denise Bertulucci Rocha Rodrigues ◽  
Sanivia Aparecida Lima Pereira ◽  
Marlene Antônia dos Reis ◽  
Sheila Jorge Adad ◽  
João Eduardo Caixeta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Proinflammatory Cytokines ◽  
Interleukin 1 ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Pemphigus Foliaceus ◽  
Endemic Pemphigus Foliaceus ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Abstract Context.—Endemic pemphigus foliaceus, or fogo selvagem, is a chronic autoimmune disease characterized by the formation of intraepidermal blisters that reduce adhesion between keratinocytes. Endemic pemphigus foliaceus is associated with the presence of autoantibodies and high levels of cytokines involved in the inflammatory response. Objectives.—To evaluate the expression of the proinflammatory cytokines interleukin 1, interferon γ, and tumor necrosis factor α; the proapoptotic inducers Fas and inducible nitric oxide synthase; and the apoptosis inhibitor Bcl-2; and to evaluate the presence of apoptosis. Design.—Skin biopsies from 13 patients with endemic pemphigus foliaceus and controls were evaluated by immunohistochemistry and apoptosis was determined by terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling assay. Results.—Proinflammatory cytokines were only detected in cells of the inflammatory exudate. Inducible nitric oxide synthase, Fas, and Bcl-2 were expressed by both epithelial and inflammatory cells. Epithelial apoptosis was observed in 12 cases (92.3%), and subepithelial apoptosis in 11 cases (85%). Conclusions.—This study suggests that apoptosis as well as the local production of proinflammatory cytokines are associated with endemic pemphigus foliaceus lesions. These results may contribute to the development of new therapeutic approaches to endemic pemphigus foliaceus.

Sign in / Sign up

Export Citation Format

Share Document