Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan synthase 2 transcripts through an AMP-activated protein kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human dermal fibroblasts

2011 ◽  
Vol 415 (2) ◽  
pp. 235-238 ◽  
Author(s):  
Takumi Yamane ◽  
Kazuo Kobayashi-Hattori ◽  
Yuichi Oishi
Keyword(s):  
Protein Kinase ◽  
Dermal Fibroblasts ◽  
Hyaluronan Synthase ◽  
Peroxisome Proliferator ◽  
Human Dermal Fibroblasts ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hyaluronan Synthase 2 ◽  
Amp Activated Protein Kinase ◽  
Dependent Pathway

scholarly journals Piper retrofractumVahl. Extract, as a PPARδand AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jungon Yun ◽  
Changhee Kim ◽  
Mi-Bo Kim ◽  
Jae-Kwan Hwang
Keyword(s):  
Protein Kinase ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mouse Skin ◽  
Adenosine Monophosphate ◽  
Dermal Fibroblasts ◽  
Mitogen Activated Protein Kinase ◽  
Peroxisome Proliferator ◽  
Human Dermal Fibroblasts ◽  
Piper Retrofractum

Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage.Piper retrofractumVahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardizedPiper retrofractumextract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin. PRE treatment activated the peroxisome proliferator-activated receptor delta (PPARδ) and the adenosine monophosphate-activated protein kinase (AMPK), consequently upregulating mitochondrial synthesis and reducing ROS production. Additionally, PRE inhibited MMPs expression via suppressing mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1). PRE downregulated UVB-induced inflammatory reactions by inhibiting the nuclear factor-kappa B (NF-κB) activity. PRE also enhanced transforming growth factor-beta (TGF-β) and the Smad signaling pathway, thereby promoting procollagen gene transcription. Furthermore, oral administration of PRE (300 mg/kg/day) similarly regulated the signaling pathways and increased antioxidant enzyme expression, thus attenuating physiological deformations, such as wrinkle formation and erythema response. Collectively, these results suggest that PRE acts as a potent antiphotoaging agent via PPARδand AMPK activation.

scholarly journals Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

2014 ◽  
Vol 66 (11) ◽  
pp. 3073-3082 ◽  
Author(s):  
Xianling Zhao ◽  
Freyr Petursson ◽  
Benoit Viollet ◽  
Martin Lotz ◽  
Robert Terkeltaub ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Amp Activated Protein Kinase
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