Glucose exposure pattern determines glucagon-like peptide 1 receptor expression and signaling through endoplasmic reticulum stress in rat insulinoma cells

2011 ◽  
Vol 414 (1) ◽  
pp. 220-225 ◽  
Author(s):  
Ye-Hwang Cheong ◽  
Mi-Kyung Kim ◽  
Moon-Ho Son ◽  
Bong-Kiun Kaang
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Receptor Expression ◽  
Glucose Exposure ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Exposure Pattern ◽  
Insulinoma Cells ◽  
Rat Insulinoma

scholarly journals Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Diabetes ◽  
2009 ◽  
Vol 58 (12) ◽  
pp. 2851-2862 ◽  
Author(s):  
Daniel A. Cunha ◽  
Laurence Ladrière ◽  
Fernanda Ortis ◽  
Mariana Igoillo-Esteve ◽  
Esteban N. Gurzov ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Dexamethasone pretreatment of rat insulinoma cells decreases binding of glucagon-like peptide-1(7–36)amide

1990 ◽  
Vol 126 (3) ◽  
pp. 445-450 ◽  
Author(s):  
G. Richter ◽  
R. Göke ◽  
B. Göke ◽  
R. Arnold
Keyword(s):  
Biological Action ◽  
Inhibitory Effects ◽  
Rinm5f Cells ◽  
Receptor Number ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Insulinoma Cells ◽  
Camp Formation ◽  
Rat Insulinoma ◽  
Stimulation Of

ABSTRACT The effect of dexamethasone on binding of glucagonlike peptide-1(7–36)amide (GLP-1(7–36)amide) to rat insulinoma-derived cells (RINm5F) was investigated. Preincubation of RINm5F cells with dexamethasone (100 nmol/l) for 24 h resulted in a decrease of GLP1(7-36)amide binding to 55·0±8·16% (mean ± s.e.m.), incubation for 48 h to 39·1±1·76%, and for 72 h to 15·5±4·35% of maximal binding. The GLP-1(7–36)amide-induced stimulation of cyclic AMP (cAMP) production was significantly decreased to 61·03±7·4% of maximum production in cells pretreated with dexamethasone (100 nmol/l) for 48 h. The decreased binding was due to a reduction of the receptor number while the receptor affinity remained unchanged. These inhibitory effects on binding and cAMP formation induced by dexamethasone were completely abolished when the antiglucocorticoid RU 38486 (100 nmol/l) was added during preincubation with dexamethasone. RU 38486 alone had no effects. Our data suggest that the biological action of GLP-1(7–36) amide at the B-cell may be modified by glucocorticoids. Journal of Endocrinology (1990) 126, 445–450

Internalization of glucagon-like peptide-1(7–36)amide in rat insulinoma cells

1989 ◽  
Vol 189 (4) ◽  
pp. 257-264 ◽  
Author(s):  
R. Göke ◽  
G. Richter ◽  
B. Göke ◽  
M. Trautmann ◽  
R. Arnold
Keyword(s):  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Insulinoma Cells ◽  
Rat Insulinoma

Glucagon-like peptide-1 production in the GLUTag cell line is impaired by free fatty acids via endoplasmic reticulum stress

Metabolism ◽  
2014 ◽  
Vol 63 (6) ◽  
pp. 800-811 ◽  
Author(s):  
Hiroto Hayashi ◽  
Ren Yamada ◽  
Siddhartha Shankar Das ◽  
Taiki Sato ◽  
Aki Takahashi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Free Fatty Acids ◽  
Cell Line ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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