Induction of ER stress protects gastric cancer cells against apoptosis induced by cisplatin and doxorubicin through activation of p38 MAPK

2011 ◽  
Vol 406 (2) ◽  
pp. 299-304 ◽  
Author(s):  
Ruo Feng ◽  
Wen Long Zhai ◽  
Hai Yan Yang ◽  
Hui Jin ◽  
Qin Xian Zhang
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Gastric Cancer Cells

scholarly journals Irinotecan Induces Autophagy-Dependent Apoptosis and Positively Regulates ROS-Related JNK- and P38-MAPK Pathways in Gastric Cancer Cells

2020 ◽  
Vol Volume 13 ◽  
pp. 2807-2817 ◽  
Author(s):  
Qingyun Zhu ◽  
Yuehui Guo ◽  
Shiwei Chen ◽  
Daiquan Fu ◽  
Yanxiang Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Gastric Cancer Cells ◽  
Mapk Pathways

Abstract 3512: Cyclopamine enhances TRAIL-induced apoptosis by induction of DR5 via ER stress in gastric cancer cells

2016 ◽  
Author(s):  
Yoo Jin Na ◽  
Dae-Hee Lee ◽  
Jung Lim Kim ◽  
Bo Ram Kim ◽  
Seong Hye Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Gastric Cancer Cells ◽  
Induced Apoptosis

scholarly journals Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Xianling Guo ◽  
Nannan Ma ◽  
Jin Wang ◽  
Jianrui Song ◽  
Xinxin Bu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Chemotherapy Resistance ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

scholarly journals Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells

2021 ◽  
Author(s):  
Tae Woo Kim
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Er Stress ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Epigenetic Modification ◽  
Autophagic Cell Death ◽  
Beclin 1 ◽  
Gastric Cancer Cells ◽  
Autophagy Inhibition

AbstractPrevious reports suggested that cinnamaldehyde (CA), the bioactive ingredient in Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities. However, the role and molecular mechanisms of CA in GC are not completely understood. In the present study, we found that CA-induced ER stress and cell death via the PERK–CHOP axis and Ca2+ release in GC cells. Inhibition of ER stress using specific–siRNA blocked CA-induced cell death. Interestingly, CA treatment resulted in autophagic cell death by inducing Beclin-1, ATG5, and LC3B expression and by inhibiting p62 expression whereas autophagy inhibition suppressed CA-induced cell death. We showed that CA induces the inhibition of G9a and the activation of LC3B. Moreover, CA inhibited G9a binding on Beclin-1 and LC3B promoter. Overall, these results suggested that CA regulates the PERK–CHOP signaling, and G9a inhibition activates autophagic cell death via ER stress in GC cells.

scholarly journals Wogonoside promotes apoptosis and ER stress in human gastric cancer cells by regulating the IRE1α pathway

2021 ◽  
Vol 21 (4) ◽  
Author(s):  
Qian Gu ◽  
Canhong Zhu ◽  
Xi Wu ◽  
Lianghuan Peng ◽  
Genya Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells

Platycodin D induces anoikis and caspase-mediated apoptosis via p38 MAPK in AGS human gastric cancer cells

2012 ◽  
Vol 114 (2) ◽  
pp. 456-470 ◽  
Author(s):  
Jaemoo Chun ◽  
Eun Ji Joo ◽  
Minseok Kang ◽  
Yeong Shik Kim
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Human Gastric Cancer ◽  
Gastric Cancer Cells ◽  
Platycodin D
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